大学化学 >> 2026, Vol. 41 >> Issue (6): 53-59.doi: 10.12461/PKU.DXHX202506066

所属专题： 化学“101计划”案例

专题 上一篇    

融合吲哚单原子骨架编辑前沿的卡宾化学教学探索——化学“101计划”有机化学课程教学案例介绍

谭芬1,2, 熊聪1, 倪宇轩1, 张之涵1, 高轲1, 肖文精1, 陆良秋1   

  1. 1 华中师范大学化学学院, 湖北 武汉 430079;
    2 湖北第二师范学院化学与生命科学学院, 湖北 武汉 430205
  • 收稿日期:2025-06-15 录用日期:2025-08-29 发布日期:2026-06-18
  • 通讯作者: 陆良秋 E-mail:luliangqiu@ccnu.edu.cn Liang-Qiu Lu
  • 基金资助:
    国家重点研发计划(2023YFA1507203)；中央高校基本科研业务费(30106190336)

Carbene chemistry teaching integrated with cutting-edge single-atom skeletal editing of indoles: a case study in organic chemistry education under the “101 Plan”

Fen Tan1,2, Cong Xiong1, Yu-Xuan Ni1, Zhihan Zhang1, Ke Gao1, Wen-Jing Xiao1, Liang-Qiu Lu1   

  1. 1 College of Chemistry, Central China Normal University, Wuhan 430079, Hubei Province, China;
    2 School of Chemistry and Life Sciences, Hubei University of Education, Wuhan 430205, Hubei Province, China
  • Received:2025-06-15 Accepted:2025-08-29 Published:2026-06-18
  • Contact: Liang-Qiu Lu E-mail:luliangqiu@ccnu.edu.cn

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摘要： 面向化学“101计划”拔尖人才培养目标，本研究以卡宾中间体为核心纽带，将单原子骨架编辑前沿成果深度融入有机化学教学。通过“理论学习-文献解析-创新设计”三阶模式，引导学生运用卡宾的基础知识解析吲哚分子单原子骨架编辑的机制。本案例为“基础知识-前沿研究”融合式教学提供可复制范式，助力有机化学课程改革。

关键词: 化学“101计划”, 课程改革, 有机化学, 卡宾, 吲哚, 单原子骨架编辑

Abstract: Aligned with the talent development objectives of the Chemistry “101 Plan”, this study employs carbene intermediates as a conceptual bridge to incorporate advanced single-atom skeletal editing research into organic chemistry pedagogy. Through a three-phase instructional model encompassing “theoretical fundamentals, literature analysis, and innovative design”, students are guided to apply foundational carbene chemistry principles to examine the mechanisms of single-atom skeletal editing in indole molecules. This teaching paradigm demonstrates a replicable approach for integrating core knowledge with frontier research, contributing to the ongoing reform of organic chemistry curricula.

Key words: Chemistry “101 Plan”, Curriculum reform, Organic chemistry, Carbene, Indole, Single-atom skeletal editing