大学化学

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钯催化Heck/插羰串联反应中酰基钯中间体介导的碳-碳键构建研究进展

乔金宝, 邵辉, 赵玉明   

  1. 陕西师范大学化学化工学院, 陕西 西安 710119
  • 收稿日期:2026-03-30 录用日期:2026-05-22
  • 通讯作者: 赵玉明 E-mail:ymzhao@snnu.edu.cn Yuming Zhao
  • 基金资助:
    陕西师范大学研究生教育教学改革研究项目(GERP-24-36)

Research progress on acylpalladium intermediate-mediated C–C bond formation in palladium-catalyzed Heck/carbonylative cascade reactions

Jinbao Qiao, Hui Shao, Yuming Zhao   

  1. School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, Shaanxi Province, China
  • Received:2026-03-30 Accepted:2026-05-22
  • Contact: Yuming Zhao E-mail:ymzhao@snnu.edu.cn

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摘要： 钯催化Heck/插羰串联反应是大学化学教学中Heck反应的重要延伸，为构建复杂环系和手性季碳中心提供了有效途径。其中，活性中间体酰基钯的转化路径直接决定了碳-碳键形成的方式与选择性。本文聚焦酰基钯中间体的两类关键终止模式：C–H官能团化及与金属试剂的转金属化/还原消除，综述了相关的研究进展、反应机理与合成应用。

关键词: Heck/插羰串联反应, 酰基钯中间体, C–H官能团化, 转金属化, 碳-碳键构建

Abstract: The palladium-catalyzed Heck/carbonylative tandem reaction serves as a significant extension of the Heck reaction in university chemistry education, offering an efficient approach for constructing complex ring systems and chiral quaternary carbon centers. The transformation pathway of the reactive acylpalladium intermediate crucially determines the mode and selectivity of carbon-carbon bond formation. This review focuses on two key termination patterns of the acylpalladium intermediate: C–H functionalization and transmetalation/reductive elimination with organometallic reagents, while summarizing relevant research advances, reaction mechanisms, and synthetic applications.

Key words: Heck/carbonylative cascade reaction, Acylpalladium intermediate, C–H functionalization, Transmetalation, Carbon-carbon bond formation