大学化学 >> 2020, Vol. 35 >> Issue (12): 35-43.doi: 10.3866/PKU.DXHX202004127

所属专题: 科学抗疫中的化学

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磷酰胺酯前药策略及ProTide技术在抗病毒药物研发中的应用

孙孝斌, 苗志伟()   

  • 收稿日期:2020-04-30 录用日期:2020-07-04 发布日期:2020-07-08
  • 通讯作者: 苗志伟 E-mail:miaozhiwei@nankai.edu.cn
  • 作者简介:苗志伟, Email: miaozhiwei@nankai.edu.cn
  • 基金资助:
    天津市科技支撑重点项目(19YFZCSN00240);南开大学中央高校基本科研业务费专项资金(63201023)

Application of Phosphoramidate Prodrugs Strategies and ProTide Technology in Anti-Virus Drug Discovery

Xiaobin Sun, Zhiwei Miao()   

  • Received:2020-04-30 Accepted:2020-07-04 Published:2020-07-08
  • Contact: Zhiwei Miao E-mail:miaozhiwei@nankai.edu.cn

摘要:

抗病毒药物是人类战胜病毒的有力武器,2019年底爆发的新型冠状病毒肺炎(COVID-19)疫情给人类带来巨大危害,同时也使人们意识到研发抗病毒药物的重要性。本文综述了磷酰胺酯前药策略及ProTide技术在抗病毒药物研发中的应用,介绍了核苷-磷酰胺酯前药的合成策略,概述了核苷-磷酰胺酯在不同抗病毒药物中的应用,为新型抗病毒药物研发提供借鉴和参考。

关键词: 抗病毒药物研发, 核苷-磷酰胺酯前药, ProTide技术

Abstract:

Antiviral drug is a powerful weapon for humans to defeat the virus. The spread of 2019 novel coronavirus pneumonia (COVID-19) outbreak has a serious impact on the world. At the same time, it also makes people aware of the importance of antiviral drug development. This article reviews the application of the phosphoramidate prodrug strategy and the application of ProTide technology in the development of antiviral drugs. The synthesis methods of nucleoside-phosphoramidate prodrugs are introduced. The application of nucleoside-phosphoramidate in different antiviral drugs is also summarized. This review can provide a reference for the development of new antiviral drugs in the future.

Key words: Anti-virus drug discovery, Nucleoside-phosphoramidate prodrugs, ProTide technology

MSC2000: 

  • G64