大学化学 >> 2025, Vol. 40 >> Issue (1): 297-302.doi: 10.12461/PKU.DXHX202404153

所属专题： 化学科普(2025)

科普 上一篇    下一篇

我不是神药——对话司美格鲁肽

郑直, 高玲燕   

  1. 西北大学化学与材料科学学院, 教育部合成与天然功能分子重点实验室, 西安 710127
  • 收稿日期:2024-04-25 录用日期:2024-09-06 发布日期:2025-01-06
  • 通讯作者: 高玲燕 E-mail:gaolingyan@nwu.edu.cn
  • 基金资助:
    西北大学2023年本科人才培养建设项目(XM05232351)；2023年国家级大学生创新创业训练计划项目(202310697127)

A Conversation with Semaglutide: Not a Miracle Drug

Zhi Zheng, Lingyan Gao   

  1. Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China
  • Received:2024-04-25 Accepted:2024-09-06 Published:2025-01-06
  • Contact: Lingyan Gao E-mail:gaolingyan@nwu.edu.cn

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摘要： 胰高血糖素样肽-1受体激动剂(glucagon like peptide-1 receptor agonists，GLP-1RAs)药物是近年来的研究热门，在降低血糖和治疗心血管疾病等领域有突出的效果，司美格鲁肽是其中的代表药物。本文以科普文的形式简要介绍司美格鲁肽的降糖机理、功能结构、副作用，以及渗透促进剂8-(2-羟基苯甲酰胺基)辛酸钠(salcaprozate sodium，SNAC)在司美格鲁肽口服制剂中的关键作用，致力于让读者在感受药物分子设计魅力的同时，进一步强化合理用药观念。

关键词: GLP-1RAs, 司美格鲁肽, SNAC, 健康, 科普

Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have garnered significant attention in recent years for their notable effects in lowering blood glucose and treating cardiovascular diseases, with semaglutide being a leading example. This article, written in a popular science format, provides a brief introduction to the hypoglycemic mechanism, functional structure, and side effects of semaglutide, as well as the critical role of the penetration enhancer salcaprozate sodium (SNAC) in its oral formulation. Through this discussion, we aim to highlight the fascinating aspects of drug design while promoting the importance of rational medication use.

Key words: GLP-1RAs, Semaglutide, SNAC, Health, Popularization of science