大学化学 >> 2026, Vol. 41 >> Issue (8): 148-161.doi: 10.12461/PKU.DXHX202507121

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烯烃1,3-双官能团化反应研究进展

张峻源1, 任向征2, 苗志伟1   

  1. 1 南开大学化学学院, 元素有机化学全国重点实验室, 天津 300071;
    2 晨虹(天津)科技股份有限公司, 天津 300400
  • 收稿日期:2025-07-28 录用日期:2025-10-15 发布日期:2026-08-25
  • 通讯作者: 苗志伟 E-mail:miaozhiwei@nankai.edu.cn Zhiwei Miao
  • 基金资助:
    国家自然科学基金面上项目(22071113)；天津市自然科学基金面上项目(24JCYBJC01960)

Research progress on 1,3-difunctionalization of alkenes

Junyuan Zhang1, Xiangzheng Ren2, Zhiwei Miao1   

  1. 1 State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China;
    2 CHAHO (Tianjin) Technology CO., LTD, Tianjin 300400, China
  • Received:2025-07-28 Accepted:2025-10-15 Published:2026-08-25
  • Contact: Zhiwei Miao E-mail:miaozhiwei@nankai.edu.cn

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摘要： 烯烃1,3-双官能团化反应通过在非相邻碳位点(α,γ)同步引入两个官能团，为复杂分子的构建提供了高效合成策略。该反应面临潜在反应位点增多、位点间距增大、1,2-与1,1-双官能团化产物的区域选择性竞争，以及多组分反应中的化学选择性等问题。通过多种催化反应策略，发展具有高区域选择性、步骤经济性和原子经济性的烯烃1,3-双官能团化反应是有机化学家关注的研究重点。本文综述了近年来烯烃1,3-双官能团化反应的研究进展，并对该领域的未来发展方向进行了展望。

关键词: 烯烃, 1,3-双官能团化, 区域选择性, 研究进展

Abstract: The 1,3-difunctionalization of alkenes offers an efficient synthetic strategy for constructing complex molecules through simultaneous introduction of two functional groups at non-adjacent carbon positions (α and γ). This transformation presents several challenges, including multiple potential reaction sites, extended distance between reactive centers, regioselective competition with 1,2- and 1,1-difunctionalized products, as well as chemoselectivity issues in multicomponent reactions. Developing catalytic systems that enable highly regioselective, step-economical, and atom-economical 1,3-difunctionalization of alkenes has become a key research focus in organic chemistry. This review summarizes recent advances in alkene 1,3-difunctionalization reactions and provides perspectives on future developments in this field.

Key words: Alkenes, 1,3-Difunctionalization, Regioselectivity, Research progress