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基于专业特色的药学分析化学实验教学设计——以钙含量测定为例的综合能力培养

乔友备, 王超丽, 唐恬, 余喆, 王珂, 席佳越, 吴红   

  1. 空军军医大学药学系药物化学与药物分析学教研室, 陕西 西安 710032
  • 收稿日期:2025-12-14 修回日期:2026-03-04
  • 通讯作者: 乔友备, 吴红 E-mail:youbei08@163.com;wuhong@fmmu.edu.cn Youbei Qiao, Hong Wu
  • 基金资助:
    空军军医大学教学改革课题YXZB2024BK021

Teaching design of analytical chemistry experiment for pharmacy major based on professional characteristics: comprehensive ability cultivation through calcium content determination

Youbei Qiao, Chaoli Wang, Tian Tang, Zhe Yu, Ke Wang, Jiayue Xi, Hong Wu   

  1. Department of Medicinal Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an 710032, Shaanxi Province, China
  • Received:2025-12-14 Revised:2026-03-04
  • Contact: Youbei Qiao, Hong Wu E-mail:youbei08@163.com;wuhong@fmmu.edu.cn

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摘要： 针对药学专业分析化学实验教学中存在的与专业背景契合度不高、学生学习兴趣不足等问题，以经典的配位滴定实验为例，进行了跨学科融合的教学改革。遵循“从生活认知到专业应用”的教学逻辑，对传统的“水硬度测定”实验进行了优化，设计了前后衔接、层层递进的两个分析项目。首先，通过“骨汤中钙含量的测定”实验，利用生活化场景降低认知门槛，让学生掌握滴定分析的基本操作技能，并直观理解分析化学在生活中的应用，激发学习兴趣。在此基础上，顺势引入“葡萄糖酸钙片中钙离子含量的测定”项目。该实验要求学生将已掌握的分析方法迁移到药品这一专业对象上，重点引导学生关注药品质量控制标准、辅料干扰排除及结果判断等药学核心问题。实践表明，这种循序渐进的实验顺序设计，逻辑思维能力和解决复杂问题的综合能力。

关键词: 分析化学实验, 教学改革, 配位滴定, 药学专业, 跨学科教学, 钙含量测定

Abstract: To address the issues of inadequate alignment with professional contexts and low student engagement in analytical chemistry experiment teaching for pharmacy majors, this study implemented cross-disciplinary teaching reforms using the classic complexometric titration experiment as a case study. Adopting a pedagogical approach that progresses “from everyday applications to professional practice”, we optimized the conventional water hardness determination experiment by designing two interconnected analytical projects with progressive complexity. The first project, “determination of calcium content in bone broth”, employs real-life scenarios to lower cognitive barriers, enabling students to acquire fundamental titration skills while appreciating the practical applications of analytical chemistry in daily life—thereby enhancing learning motivation. Subsequently, the second project, “determination of calcium ion content in calcium gluconate tablets”, challenges students to transfer their acquired analytical techniques to pharmaceutical contexts, emphasizing critical pharmaceutical considerations such as drug quality control standards, interference elimination from excipients, and result interpretation. This sequential experimental design has demonstrated effectiveness in fostering students’ logical reasoning and comprehensive problemsolving abilities.

Key words: Analytical chemistry experiment, Teaching reform, Coordination titration, Pharmacy major, Interdisciplinary teaching, Determination of calcium content