走近Catellani反应：从经典偶联到芳环多位点精准官能团化

doi:10.12461/PKU.DXHX202608050

大学化学

走近Catellani反应：从经典偶联到芳环多位点精准官能团化

孟郑正, 赵力颖, 周强辉, 程鸿刚

武汉大学化学与分子科学学院, 湖北武汉 430072

收稿日期:2026-08-15 录用日期:2026-09-11
通讯作者: 程鸿刚 E-mail:hgcheng@whu.edu.cn Hong-Gang Cheng

The Catellani reaction: from classical cross-coupling to siteselective and modular functionalization of aromatics

Zhengzheng Meng, Liying Zhao, Qianghui Zhou, Hong-Gang Cheng

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei Province, China

Received:2026-08-15 Accepted:2026-09-11
Contact: Hong-Gang Cheng E-mail:hgcheng@whu.edu.cn

摘要/Abstract

摘要： Catellani反应是钯催化领域中的一个人名反应，利用钯/降冰片烯协同催化，依次实现芳基卤化物邻位C–H键官能团化及卤素位点偶联反应，从而高效构建多取代芳烃。本文介绍了其发现背景、催化机理、研究进展及在天然产物全合成中的代表性应用，并探讨其在本科有机化学教学中的价值，以期为有机化学教学与科研实践提供参考。

关键词: Catellani反应, 钯催化, 降冰片烯, 多取代芳烃, 本科教学

Abstract: The Catellani reaction is a named reaction in palladium catalysis that leverages palladium/norbornene cooperative catalysis to achieve sequential ortho C–H functionalization of aryl halides and ipso coupling at the halogen site, thereby enabling the efficient construction of polysubstituted arenes. This article introduces its discovery background, catalytic mechanism, research progress, and representative applications in the total synthesis of natural products, and discusses its value in undergraduate organic chemistry education, with the aim of providing a reference for organic chemistry teaching and research practice.

Key words: Catellani reaction, Palladium catalysis, Norbornene, Polysubstituted arenes, Undergraduate teaching

孟郑正, 赵力颖, 周强辉, 程鸿刚. 走近Catellani反应：从经典偶联到芳环多位点精准官能团化[J]. 大学化学, 2026, (): 2608050.

Zhengzheng Meng, Liying Zhao, Qianghui Zhou, Hong-Gang Cheng. The Catellani reaction: from classical cross-coupling to siteselective and modular functionalization of aromatics[J]. University Chemistry, 2026, (): 2608050.

链接本文: https://www.dxhx.pku.edu.cn/CN/10.12461/PKU.DXHX202608050

https://www.dxhx.pku.edu.cn/CN/Y2026/V/I/2608050

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