大学化学 >> 2016, Vol. 31 >> Issue (5): 60-64.doi: 10.3866/PKU.DXHX201506011

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α-联苯双酯合成的绿色化学探索

边磊,关玲,徐烜峰,高杨,张奇涵*()   

  • 发布日期:2016-05-23
  • 通讯作者: 张奇涵 E-mail:zqh@pku.edu.cn

Exploration on Green Chemical Synthesis of α-Biphenyldicarboxylate

Lei BIAN,Ling GUAN,Xuan-Feng XU,Yang GAO,Qi-Han ZHANG*()   

  • Published:2016-05-23
  • Contact: Qi-Han ZHANG E-mail:zqh@pku.edu.cn

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摘要：

α-联苯双酯的绿色化学合成是一个面向大学二年级本科生的探索性实验。实验以没食子酸为原料,用安全低毒的碳酸二甲酯和二溴海因替代传统生产工艺中剧毒的硫酸二甲酯和强腐蚀性的溴素,制备α-联苯双酯。探索了一条适合本科生实验教学的制备α-联苯双酯的绿色合成路线。

关键词: α-联苯双酯, 碳酸二甲酯, 二溴海因, 绿色化学

Abstract:

Green synthesis of α-biphenyldicarboxylate(α-DDB) is an exploratory experiment for secondyear undergraduates. The α-DDB is synthesized by using gallic acid as the starting material. Two safe and low toxic reagents, dimethyl carbonate(DMC) and 1,3-dibromo-5,5-dimethylhydantoin(DBDMH) were used to replace extremely toxic dimethyl sulfate(DMS) and strongly corrosive and toxic bromine, respectively. The feasibilty of green chemical synthesis of α-DDB has been explored and realized in laboratory teaching.

Key words: α-DDB, DMC, DBDMH, Green chemistry