大学化学 >> 2022, Vol. 37 >> Issue (12): 2111076.doi: 10.3866/PKU.DXHX202111076

化学实验 上一篇    下一篇

阿司匹林合成过程在线分析实验教学实践

姚志湘, 马鑫, 张景清, 苏誉婷, 粟晖()   

  • 收稿日期:2021-11-26 录用日期:2022-01-02 发布日期:2022-03-01
  • 通讯作者: 粟晖 E-mail:suhui@gxust.edu.cn
  • 作者简介:粟晖, Email: suhui@gxust.edu.cn
  • 基金资助:
    广西高等教育本科教学改革工程项目(2021JGB232)

Laboratory Teaching Practice of On-Line Analysis of Aspirin Synthesis Process

Zhixiang Yao, Xin Ma, Jingqing Zhang, Yuting Su, Hui Su()   

  • Received:2021-11-26 Accepted:2022-01-02 Published:2022-03-01
  • Contact: Hui Su E-mail:suhui@gxust.edu.cn

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摘要：

针对阿司匹林合成过程在线分析实验内容，采用基于子空间角度转换的化学计量学方法，通过求取反应体系拉曼光谱响应与阿司匹林对照品光谱的角度值，实现阿司匹林合成产物的无损定量分析和反应过程趋势跟踪。通过在教学中引入过程分析技术(PAT)的观念和教师科研成果，实施实验教学改革，让学生对新技术产生直接认识，拓宽了学生的视野，提高了学生的学习兴趣、综合素质和创新能力。

关键词: 阿司匹林, 过程分析技术, 新工科, 化学测量学与技术

Abstract:

The paper, according to the online measuring of aspirin synthesis process, employs the chemometrics method based on the subspace-angle transformations to realize the nondestructive quantification and the trend tracking of aspirin synthesis products. The quantitative relation is the angle value of Raman spectra between the reaction system and the pure aspirin. On the concept introducing for the process analysis technology (PAT) and teachers' research improvements into the laboratory class, the reform on laboratory teaching is implemented, which enables students to have a direct understanding of new technology. The benefits to students include the broadening of vision, and the improvement of the learn-interest, and the quality and ability of enhancing the innovation.

Key words: Aspirin, Process analysis technology (PAT), Emerging engineering education, Chemistry metrology and technology