大学化学 >> 2023, Vol. 38 >> Issue (11): 223-229.doi: 10.3866/PKU.DXHX202304058

化学实验 上一篇    下一篇

有机化学实验的副产物分析引导实验创新与科研素养培育——以4-苯基丁-2-酮合成实验为例

陈建军(), 曹月洋, 陈万红, 黄国生(), 高坤()   

  • 收稿日期:2023-04-18 录用日期:2023-06-12 发布日期:2023-06-21
  • 通讯作者: 陈建军,黄国生,高坤 E-mail:chenjj@lzu.edu.cn;hgs2368@163.com;npchem@lzu.edu.cn
  • 基金资助:
    兰州大学教育教学改革研究项目(JYXM-2020-05);国家自然科学基金项目(81973193);国家自然科学基金项目(22277045)

Side Reaction Products Analysis of Organic Chemistry Experiments to Guide Experimental Innovation and Improve Scientific Research Literacy: Synthesis of 4-Phenylbutyl-2-ketone

Jianjun Chen(), Yueyang Cao, Wanhong Chen, Guosheng Huang(), Kun Gao()   

  • Received:2023-04-18 Accepted:2023-06-12 Published:2023-06-21
  • Contact: Jianjun Chen, Guosheng Huang, Kun Gao E-mail:chenjj@lzu.edu.cn;hgs2368@163.com;npchem@lzu.edu.cn

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摘要：

用乙酰乙酸乙酯和氯化苄合成4-苯基丁-2-酮是经典的有机化学实验，但该实验的产率仅有20%–30%。本文记录了教师通过引导学生分离实验中的副产物，确定其为2,2-二苄基-3-氧代丁酸乙酯，并分析该副产物产生的原因，进而启发学生创新实验方案将产率提高至57.5%的过程。该教学实践不仅引导学生进行实验创新，而且培养了学生的科研素养。

关键词: 4-苯基丁-2-酮, 实验创新, 提升产率, 科研素养

Abstract:

The synthesis of 4-phenyl buty-2-ketone from ethyl acetoacetate and benzyl chloride is a classical organic chemistry experiment, but the yield is only 20%–30% in practical teaching. This paper records the process of teachers guiding students to separate the byproduct in the experiment, determines it as 2,2-dibenzyl-3-oxybutyrate, analyzes the causes of the byproduct, and inspires the students to innovate the experimental method to increase the yield to 57.5%. This teaching practice not only guides students with regard to experimental innovation but also improves the scientific research literacy of students.

Key words: 4-Phenyl buty-2-ketone, Experimental innovation, Improvement of reaction yield, Scientific research literacy