大学化学 >> 2023, Vol. 38 >> Issue (12): 38-44.doi: 10.3866/PKU.DXHX202306072

所属专题： 大学化学基础与创新药物研发前沿

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融入结构可视化与创新药物案例的配位化学教学

谢周令1, 张茹1, 王琴2,*(), 廖晨钟1,*()   

  1. 1 合肥工业大学食品与生物工程学院, 药物科学与工程系, 合肥 230009
    2 安徽医科大学第一附属医院耳鼻咽喉科头颈外科, 合肥 230022
  • 收稿日期:2023-06-28 录用日期:2023-08-31 发布日期:2023-09-07
  • 通讯作者: 王琴,廖晨钟 E-mail:wangqin@ahmu.edu.cn;czliao@hfut.edu.cn
  • 基金资助:
    合肥工业大学青年教师教研项目(JYQN2221);安徽省重点研究与开发计划(2022i01020004)

Integrating Structural Visualization and Innovative Drug Cases into the Teaching of Coordination Chemistry

Zhouling Xie1, Ru Zhang1, Qin Wang2,*(), Chenzhong Liao1,*()   

  1. 1 Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
    2 Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
  • Received:2023-06-28 Accepted:2023-08-31 Published:2023-09-07
  • Contact: Qin Wang, Chenzhong Liao E-mail:wangqin@ahmu.edu.cn;czliao@hfut.edu.cn

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摘要：

创新药物研发是医药产业发展的核心驱动力。培养一大批具有扎实药物研发知识背景的药学本科生投身药物研发具有重要的意义。目前，大部分院校的本科生培养模式存在基础课程和药学专业课程的割裂，这种割裂使学生在大学早期无法将基础化学知识与创新药物研发联系在一起，失去了让学生尽早构建药物研发知识体系的机会，更减少了教学的趣味性和科研启蒙意义。本文以无机化学的配位化学教学为例，尝试将结构可视化和创新药物案例融入教学过程，提升教学内容的专业性、创新性和高阶性，以适应高素质药学人才培养的需求，激发大学生从事新药研发的热情，打破基础课程与专业课程之间的壁垒。该教学方法可以扩展和应用到有机化学、药物化学等其他课程的教学中。

关键词: 创新药物, 配位化学, 教学改革, 案例教学

Abstract:

Innovative drug development is the central driving force of the pharmaceutical industry. Cultivating a large cohort of pharmacy undergraduates with a solid background in drug development research is of significant importance. Currently, the majority of educational institutions feature a disjointed approach between foundational courses and specialized pharmacy courses. This disconnection prevents students from integrating basic chemistry knowledge with innovative drug development research during their early academic years. As a result, students lose the opportunity to build a comprehensive understanding of drug development, thereby diminishing the appeal and formative potential of the education. This paper uses the teaching of coordination chemistry in inorganic chemistry as an example, attempting to incorporate structural visualization and case studies of innovative drugs into the curriculum. The goal is to elevate the subject matter's professionalism, innovation, and advanced nature to meet the demands of high-quality pharmaceutical talent development and to inspire undergraduates to engage in new drug research by bridging the gap between foundational and specialized courses. This teaching approach can be extended and applied to other courses like organic chemistry and medicinal chemistry.

Key words: Innovative drug, Coordination chemistry, Teaching reform, Case-based teaching