“铁盐+空气”催化氧化体系在绿色交叉偶联反应中的应用——推荐一个本科生科研训练项目

doi:10.3866/PKU.DXHX202201046

大学化学 >> 2023, Vol. 38 >> Issue (1): 295-303.doi: 10.3866/PKU.DXHX202201046

未来化学家上一篇

“铁盐+空气”催化氧化体系在绿色交叉偶联反应中的应用——推荐一个本科生科研训练项目

李若璞, 徐一泽, 胡仁铭, 赖易欢, 徐大振()

南开大学化学学院，天津 300071

收稿日期:2022-01-23 录用日期:2022-03-24 发布日期:2022-04-08
通讯作者: 徐大振 E-mail:xudazhen@nankai.edu.cn
基金资助:
国家级大学生创新创业训练计划(201810055095);国家级大学生创新创业训练计划(202110055069)

Application of "Iron Salt + Air" Catalytic Oxidation System in Green Cross Coupling Reaction: Recommendation for an Undergraduate Research-Training Program

Ruopu Li, Yize Xu, Renming Hu, Yihuan Lai, Dazhen Xu()

College of Chemistry, Nankai University, Tianjin 300071, China

Received:2022-01-23 Accepted:2022-03-24 Published:2022-04-08
Contact: Dazhen Xu E-mail:xudazhen@nankai.edu.cn

摘要/Abstract

摘要：

为深入开展创新创业教育与实践，培养学生创新创业能力，提高本科生人才培养质量，进一步推动创新创业教育改革，南开大学开展了“国家级大学生创新创业训练计划”项目。化学学院结合学科自身特点，践行科教融合、理论联系实际的培养方法，不仅能够引导本科生积极参加科研训练，还能将本科生的创新结果应用于实际生产中。实现“科研反哺教学”与“教学支撑科研”这样一个相互补充、相互促进的统一体。本文介绍了一组比较典型的本科生参与“国创”项目的例子，从项目准备入手介绍了该“国创”项目的具体实施过程、同学们所遇困难及收获心得等，希望将我们积累的一些经验与化学相关专业的同学分享，助力他们更好地完成创新项目。

关键词: 本科生创新科研训练, 国创项目, "铁盐+空气"催化氧化体系, 绿色交叉偶联反应

Abstract:

In order to extend innovation and entrepreneurship education and practice, cultivate the students' innovation and entrepreneurship ability, improve undergraduate education quality, and further promote the reform of innovation and entrepreneurship education, a project called "National College Students' Innovation and Entrepreneurship Training Program" has been carried out in Nankai University. In addition to details of the chemical discipline, methods for integrating science and education, as well as integrating theory with practice have been taught in the college of chemistry. In this program, undergraduates were not only guided to actively participate in scientific research training, but also to apply their innovative results in practice. A unified system of mutual complementarity and mutual promotion between "scientific research feeding into teaching" and "teaching supporting scientific research" has been realized. In this paper, a typical example of undergraduate students participating in this training program is introduced. Details from the preparation to the specific implementation process of the program, including difficulties, experiences, and successes of the project are shown, with the hopes of sharing our experience with other undergraduates majoring in chemistry and helping them improve their innovative projects.

Key words: Undergraduate innovative scientific research training, National college students' innovation and entrepreneurship training program, "Iron salt + air" catalytic oxidation system, Green cross-dehydrogenative coupling reaction

李若璞, 徐一泽, 胡仁铭, 赖易欢, 徐大振. “铁盐+空气”催化氧化体系在绿色交叉偶联反应中的应用——推荐一个本科生科研训练项目[J]. 大学化学, 2023, 38(1): 295-303.

Ruopu Li, Yize Xu, Renming Hu, Yihuan Lai, Dazhen Xu. Application of "Iron Salt + Air" Catalytic Oxidation System in Green Cross Coupling Reaction: Recommendation for an Undergraduate Research-Training Program[J]. University Chemistry, 2023, 38(1): 295-303.

链接本文: https://www.dxhx.pku.edu.cn/CN/10.3866/PKU.DXHX202201046

https://www.dxhx.pku.edu.cn/CN/Y2023/V38/I1/295

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Entry	Cat (10 mol%)	Solvent (mL)	T/℃	Time (h)	Yield/% ^b
1	FeCl₃	EtOH	80	5	trace
2	FeCl₃	CH₃CN	80	5	trace
3	FeCl₃	DMF	80	5	45
4	FeBr₃	DMF	80	6	57
5	Fe(NO₃)₃∙9H₂O	DMF	80	6	62
6	Fe(OTf)₃	DMF	80	5	21
7	Fe₂(SO₄)₃∙xH₂O	DMF	80	7	65
8	FeCl₂∙4H₂O	DMF	80	5	54
9	Fe(OAc)₂	DMF	80	5	93
10	PhCOOH	DMF	80	6	–
11 ^c	Fe(OAc)₂	DMF	80	7.5	84
12	–	DMF	80	6	–


Entry	Cat (10 mol%)	Acid (15 mol%)	T/℃	Yield/% ^b
1	FeCl₃∙6H₂O	–	80	42
2	FeCl₃∙6H₂O	p-TSA	80	68
3	–	p-TSA	80	–
4	FeCl₃	p-TSA	80	83
5	FeBr₃	p-TSA	80	69
6	Fe₂(SO₄)₃∙xH₂O	p-TSA	80	81
7	FeCl₂∙4H₂O	p-TSA	80	60
8	Cu(OAc)₂∙H₂O	p-TSA	80	–
10	FeCl₃	TFA	80	75
11	FeCl₃	PhCO₂H	80	43

“铁盐+空气”催化氧化体系在绿色交叉偶联反应中的应用——推荐一个本科生科研训练项目

Application of "Iron Salt + Air" Catalytic Oxidation System in Green Cross Coupling Reaction: Recommendation for an Undergraduate Research-Training Program

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