大学化学 >> 2025, Vol. 40 >> Issue (5): 357-365.doi: 10.12461/PKU.DXHX202407028

所属专题： 有机电化学

化学实验 上一篇    下一篇

电化学制备2,5-二苯基-1,3,4-噁二唑——推荐一个综合性有机化学实验

李姝慧, 黄荣秀媛, 潘英明   

  1. 广西师范大学化学与药学学院, 省部共建药用资源化学与药物分子工程国家重点实验室, 广西 桂林 541004
  • 收稿日期:2024-07-02 修回日期:2024-11-11 发布日期:2025-05-21
  • 通讯作者: 潘英明 E-mail:panym@mailbox.gxnu.edu.cn
  • 基金资助:
    国家级第二批一流本科课程线下一流课程“有机化学”；广西壮族自治区级一流本科课程线下一流课程“有机化学”(桂教高教[2021]11号)；广西壮族自治区级课程思政示范课程“有机化学”(桂教高教[2022]52号)；广西高等教育本科教学改革工程项目(2023JGB133,2024JGZ113)；广西师范大学“专(思)创融合”示范课程建设项目(师政教学[2024]133号)；研究生课程思政示范课程建设项目(师政教学[2024]78号)

Electrochemical Synthesis of 2,5-Diphenyl-1,3,4-Oxadiazole: A Recommended Comprehensive Organic Chemistry Experiment

Shuhui Li, Rongxiuyuan Huang, Yingming Pan   

  1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, Guangxi, China
  • Received:2024-07-02 Revised:2024-11-11 Published:2025-05-21
  • Contact: Yingming Pan E-mail:panym@mailbox.gxnu.edu.cn

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摘要： 本实验采用电化学合成方法，以苯甲酰肼为原料制备2,5-二苯基-1,3,4-噁二唑，并通过核磁、红外、熔点等分析技术对其进行结构鉴定与表征。与传统有机合成方法相比，电化学合成方法符合绿色化学的要求，具有操作简单、条件温和、产率较高等优点。此实验引导学生在掌握了有机基础实验的前提下，对前沿电化学合成方法进行探索研究，并进一步了解电化学在有机合成方面的应用，培养学生的科研兴趣以及创新的科研思维，丰富有机基础实验教学内容。

关键词: 电化学, 2,5-二苯基-1,3,4-噁二唑, 化学实验教学, 有机合成

Abstract: This experiment employs an electrochemical synthesis method to produce 2,5-diphenyl-1,3,4-oxadiazole from benzoylhydrazine. The structure of the synthesized product is identified and characterized using analytical techniques, including NMR, infrared spectroscopy, and melting point determination. In comparison to traditional organic synthesis methods, the electrochemical approach aligns with green chemistry principles, offering advantages such as simplicity, mild reaction conditions, and high yield. This experiment encourages students, who have mastered fundamental organic laboratory techniques, to explore cutting-edge electrochemical synthesis methods and gain insights into the application of electrochemistry in organic synthesis. Additionally, it fosters students’ interest in scientific research and innovative thinking, thereby enriching the content of basic organic chemistry education.

Key words: Electrochemistry, 2,5-Diphenyl-1,3,4-oxadiazole, Chemical experimental teaching, Organic synthesis