大学化学 >> 2026, Vol. 41 >> Issue (7): 319-325.doi: 10.12461/PKU.DXHX202506036

化学实验 上一篇    

利用自制简易流动合成反应仪制备2-(4-氯亚苄基)丙二腈——推荐一个化学综合实验

王一诺, 干浥尘, 李珂宇, 徐大振   

  1. 南开大学化学学院, 农药国家工程研究中心, 天津 300071
  • 收稿日期:2025-06-10 录用日期:2025-08-04 发布日期:2026-06-27
  • 通讯作者: 徐大振 E-mail:xudazhen@nankai.edu.cn Dazhen Xu
  • 基金资助:
    国家级大学生创新创业训练计划(202310055078)

Synthesis of 2-(4-Chlorobenzylidene) malononitrile via a self-made continuous flow reactor: a proposed comprehensive chemistry experiment

Yinuo Wang, Yichen Gan, Keyu Li, Dazhen Xu   

  1. National Engineering Research Center of Pesticide, College of Chemistry, Nankai University, Tianjin 300071, China
  • Received:2025-06-10 Accepted:2025-08-04 Published:2026-06-27
  • Contact: Dazhen Xu E-mail:xudazhen@nankai.edu.cn

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摘要： 连续流反应由于其操作安全、反应高效、环境友好等优点，近年来在合成领域中得到广泛应用。本实验设计了一种连续流反应，在聚苯乙烯材料上负载1,4-二氮杂双环[2.2.2]辛烷(DABCO)作为可循环催化剂，催化4-氯苯甲醛与丙二腈间的Knoevenagel缩合反应，绿色、高效合成2-(4-氯亚苄基)丙二腈。本实验将教材中经典的有机反应与科研前沿相结合，在帮助学生巩固理论的基础上，引入新型的连续流反应激发学生的学习兴趣，鼓励学生对经典有机反应制备过程进行优化，培养善于思考、勇于创新的综合型人才。

关键词: 连续流反应, Knoevenagel缩合, 负载催化剂, 有机合成

Abstract: Continuous flow reactions have gained widespread application in synthetic chemistry in recent years owing to their operational safety, high efficiency, and environmental friendliness. This experiment presents a continuous flow system employing polystyrene-immobilized 1,4-diazabicyclo[2.2.2]octane (DABCO) as a recyclable catalyst for the Knoevenagel condensation between 4-chlorobenzaldehyde and malononitrile, enabling the green and efficient synthesis of 2-(4-chlorobenzylidene)malononitrile. By integrating fundamental organic reactions from textbooks with contemporary research methodologies, this experiment not only reinforces students’ theoretical knowledge but also introduces innovative continuous flow technology to stimulate learning interest. The approach encourages students to optimize traditional organic synthesis processes, fostering the development of critical thinking and innovation skills in future chemists.

Key words: Continuous flow reaction, Knoevenagel condensation, Immobilized catalyst, Organic Synthesis