大学化学 >> 2026, Vol. 41 >> Issue (8): 210-219.doi: 10.12461/PKU.DXHX202508014

科普 上一篇    下一篇

当超分子二肽遇上酸碱指示剂：热响应水凝胶的智能可视化

雷子文, 刘明胤, 石佳怡, 单雅函, 张琦   

  1. 华东理工大学化学与分子工程学院, 费林加诺贝尔奖科学家联合研究中心, 上海 200237
  • 收稿日期:2025-08-05 录用日期:2025-09-30 发布日期:2026-08-25
  • 通讯作者: 单雅函, 张琦 E-mail:y.shan@ecust.edu.cn;q.zhang@ecust.edu.cn Yahan Shan, Qi Zhang
  • 基金资助:
    国家自然科学基金项目(22475070,22505078)；上海市浦江人才项目(23PJ1402100)；上海市晨光学者项目

Coupling thermo-responsive supramolecular dipeptides self-assembly with pH indicators for visualizable dynamic hydrogel

Ziwen Lei, Mingyin Liu, Jiayi Shi, Yahan Shan, Qi Zhang   

  1. Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China
  • Received:2025-08-05 Accepted:2025-09-30 Published:2026-08-25
  • Contact: Yahan Shan, Qi Zhang E-mail:y.shan@ecust.edu.cn;q.zhang@ecust.edu.cn

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摘要： 将苯酚红、溴甲酚氯等酸碱指示剂与小分子二肽Fmoc-FF构筑的水凝胶相结合，利用酸碱指示剂的变色特性探究多肽水凝胶的pH响应。同时也利用水凝胶的热响应性设计了一系列的科普互动实验。通过这些科普实验，旨在引导学生学习酸碱指示剂变色原理与水凝胶热响应原理的作用机制。此外，通过简单的实验验证，使学生能够将水凝胶的凝胶-溶液可逆相转变与直观的颜色变化相耦合，提升了科普实验的趣味性，并激发了实验者进一步利用这些性质开发更加个性化的艺术创作，探索科学之美。

关键词: 超分子水凝胶, 酸碱指示剂, 科普实验, 多肽自组装

Abstract: Taking advantage of color-switchable property of acid/base indicators, this experiment explored the pH-responsive ability of a hydrogel formed by a dipeptide molecule (Fmoc-FF) by introducing the phenol red and bromocresol chloride. Meanwhile, a series of interactive chemical experiments were designed based on the thermoresponsive property of the hydrogel. These easy-to-make experiments facilitate the learning and understanding of undergraduate students on acid/base indicators and thermos-responsive hydrogels. In addition, the students can clearly observe the reversible transition processes from gel state to solution state and multiple color changes of hydrogels, which could help students to carry out a series of diverse artistic creations.

Key words: Supramolecular hydrogel, pH Indicator, Popular science experiment, Dipeptide self-assembly