关键词: 药学本科, 有机化学实验, 系统化思维, 香豆素查尔酮衍生物

Abstract: Addressing the demands of New Medical Education for cultivating innovative pharmaceutical talents, this study tackles the shortcomings of conventional organic chemistry experiments in pharmacy programs—where verification-based exercises dominate, leading to passive student participation without comprehensive understanding of experimental design, reaction mechanisms, or drug development logic. We established a three-stage progressive project-based teaching system comprising “theoretical foundation - innovative design - comprehensive practice”, using the innovative synthesis of coumarin-chalcone derivatives as a model drug scaffold. This framework synergizes theoretical instruction with experimental investigation, promotes creative synthesis strategy development, and implements interdisciplinary structural characterization training. The approach systematically nurtures students’ scientific thinking from molecular design to structural elucidation while strengthening core pharmaceutical competencies, offering an implementable model for experimental pedagogy reform in pharmaceutical education under the New Medical Education framework.

Key words: Pharmacy undergraduate, Organic chemistry experiment, Systems thinking, Coumarin-chalcone hybrids