University Chemistry ›› 2018, Vol. 33 ›› Issue (1): 69-72.doi: 10.3866/PKU.DXHX201707014

• Chemistry Laboratory • Previous Articles     Next Articles

Preparation of 5-Methoxy-2-Phenyl-2, 3-Dihydrobenzofuran: A Comprehensive College Chemistry Experiment

Yunxia WANG*(),Yu ZHAO,Lanying WANG,Jianli LI   

  • Received:2017-07-12 Published:2018-01-13
  • Contact: Yunxia WANG E-mail:wyx27210@nwu.edu.cn
  • Supported by:
    西北大学质量与教学改革工程项目(JX14046);陕西省科技计划项目(2017KW-066);西安市科技计划项目;西北大学合成与天然功能分子化学教育部重点实验室开放基金

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Abstract:

A new comprehensive college chemistry experiment was introduced. 5-Methoxy-2-phenyl-2, 3-dihydrobenzofuran was prepared from 4-methoxyphenol and styrene by using 1, 1, 1, 3, 3, 3-hexafluoropropan-2-ol as the solvent and 2, 3-dichloro-5, 6-dicyanobenzoquinone as the oxidant at room temperature. The structure was identified by IR, 1H NMR, 13C NMR and HRMS. In the experiment, students' research interest and exploring spirit will be stimulated, the skill of comprehensive experiment operation and analysis will be improved, and furthermore, the innovative thinking and scientific research ability will be cultivated.

Key words: 5-Methoxy-2-phenyl-2, 3-dihydrobenzofuran, 4-Methoxy-phenol, Styrene