氮杂环卡宾催化的亲核取代反应

doi:10.3866/PKU.DXHX202004042

Abstract

Abstract:

Great progress has been made in N-heterocyclic carbene (NHC) catalyzed. In the reaction, NHCs are mainly used for the umpolung of aldehydes from electrophilic to nucleophilic. In this paper, the NHC-catalyzed nucleophilic substitution is described in detail; the umpolung of aldehyde and the corresponding substrate react through S_N1, S_N2, S_N2', addition-elimination, elimination-addition processes. The introduction of the substitution reaction of aldehyde as a nucleophile can enrich and extension the content of the knowledge of aldehyde with ketone in undergraduate curriculum. It is also helpful for the students to understand the cutting-edge development of the discipline, and stimulate students' interest in exploration and learning.

Key words: N-Heterocyclic carbene, Organocatalysis, Nucleophilic substitution, Aldehyde

Ming Zhao, Liqing Yang, Yurong Xu. N-Heterocyclic Carbene Catalyzed Nucleophilic Substitution Reaction[J].University Chemistry, 2021, 36(4): 2004042.

Figures/Tables 11

References 21

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N-Heterocyclic Carbene Catalyzed Nucleophilic Substitution Reaction

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