University Chemistry ›› 2023, Vol. 38 ›› Issue (11): 223-229.doi: 10.3866/PKU.DXHX202304058

• Chemistry Laboratory • Previous Articles     Next Articles

Side Reaction Products Analysis of Organic Chemistry Experiments to Guide Experimental Innovation and Improve Scientific Research Literacy: Synthesis of 4-Phenylbutyl-2-ketone

Jianjun Chen(), Yueyang Cao, Wanhong Chen, Guosheng Huang(), Kun Gao()   

  • Received:2023-04-18 Accepted:2023-06-12 Published:2023-06-21
  • Contact: Jianjun Chen, Guosheng Huang, Kun Gao E-mail:chenjj@lzu.edu.cn;hgs2368@163.com;npchem@lzu.edu.cn

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Abstract:

The synthesis of 4-phenyl buty-2-ketone from ethyl acetoacetate and benzyl chloride is a classical organic chemistry experiment, but the yield is only 20%–30% in practical teaching. This paper records the process of teachers guiding students to separate the byproduct in the experiment, determines it as 2,2-dibenzyl-3-oxybutyrate, analyzes the causes of the byproduct, and inspires the students to innovate the experimental method to increase the yield to 57.5%. This teaching practice not only guides students with regard to experimental innovation but also improves the scientific research literacy of students.

Key words: 4-Phenyl buty-2-ketone, Experimental innovation, Improvement of reaction yield, Scientific research literacy