我不是神药——对话司美格鲁肽

doi:10.12461/PKU.DXHX202404153

Abstract

Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have garnered significant attention in recent years for their notable effects in lowering blood glucose and treating cardiovascular diseases, with semaglutide being a leading example. This article, written in a popular science format, provides a brief introduction to the hypoglycemic mechanism, functional structure, and side effects of semaglutide, as well as the critical role of the penetration enhancer salcaprozate sodium (SNAC) in its oral formulation. Through this discussion, we aim to highlight the fascinating aspects of drug design while promoting the importance of rational medication use.

Key words: GLP-1RAs, Semaglutide, SNAC, Health, Popularization of science

Zhi Zheng, Lingyan Gao. A Conversation with Semaglutide: Not a Miracle Drug[J].University Chemistry, 2025, 40(1): 297-302.

[1]	Lingqi Zhang, Hairong Huang, Jialin Li, Li Ji, Yufan Pan, Meiling Ye, Cuixue Chen, Shunü Peng. Green Preparation and Popular Science Applications of Osmanthus-Derived Carbon Quantum Dots [J]. University Chemistry, 2025, 40(8): 298-306.
[2]	Yuxia Luo, Xiaoyu Xie, Fangfang Chen. The Magician of Drug Delivery: Molecularly Imprinted Polymers [J]. University Chemistry, 2025, 40(8): 202-210.
[3]	Shengli Chen, Xinxin Zhao, Mingxue Xing, Xintai Li, Xiaojie Zhang, Xiuli Hu, Jimin Zhang. “Hair-Trigger”: The Magical Collision of Polycarboxylate Superplasticizers and Cement [J]. University Chemistry, 2025, 40(8): 315-322.
[4]	Tianyang Yu, Hao Wei. “Illness Enters through the Mouth”: A Brief Overview of Toxic Chemical Substances in Common Foods [J]. University Chemistry, 2025, 40(7): 225-231.
[5]	Ying Liu, Jia Ji, Yinling Hou, Lilan Guo, Xuan Lv. Selenium’s Journey [J]. University Chemistry, 2025, 40(7): 218-224.
[6]	Chi Zhang, Yi Xu, Xiaopeng Guo, Zian Jie, Ling Li. The Vibrant Secrets: Mechanism of Coloration in Materials [J]. University Chemistry, 2025, 40(6): 266-275.
[7]	Qianlang Wang, Jijun Sun, Qian Chen, Quanqin Zhao, Baojuan Xi. The Appeal of Organophosphorus Compounds: Clearing Their Name [J]. University Chemistry, 2025, 40(4): 299-306.
[8]	Jijun Sun, Qianlang Wang, Qian Chen, Quanqin Zhao, Shumei Zhai. The Antibiotic Legion’s Manifesto to Human Allies [J]. University Chemistry, 2025, 40(4): 307-321.
[9]	Yidan Jing, Xiaomin Zhang, Nan Xu. Design and Practice of Chemical Science Popularization Experiments Based on the Concept of Controlling Variables: Taking the “Recovery of Silver from Silver-Containing Wastewater” Science Popularization Project as an Example [J]. University Chemistry, 2025, 40(4): 346-352.
[10]	Yufan Pan, Xue Ding, Jiayu Lin, Haiting Wu, Hairong Huang, Cuixue Chen, Meiling Ye. Oil Cosmetics, Charming Chemistry: A Gradient Science Popularization Scheme for Cream Cosmetic Preparation [J]. University Chemistry, 2025, 40(4): 382-389.
[11]	Qianqian Wang, Haoyu Ma, Zhen Wang, Gang Xie. The Extraordinary World of Hard Carbon [J]. University Chemistry, 2025, 40(2): 267-271.
[12]	Xiqing Liang, Tian Zhao, Jiawei Li, Haohui Tan, Hai Chen, Liyan Zeng. Pentaerythritol’s Journey of Making Friends [J]. University Chemistry, 2025, 40(10): 175-185.
[13]	Qin Li, Kexin Yang, Qinglin Yang, Xiangjin Zhu, Xiaole Han, Tao Huang. Illuminating Chlorophyll: Innovative Chemistry Popularization Experiment [J]. University Chemistry, 2024, 39(9): 359-368.
[14]	Wei Gao, Jinyue Yang, Wenwei Zhang. Practice and Exploration of Promoting the “Double Reduction” Work with Popular Science Resources in Universities [J]. University Chemistry, 2024, 39(9): 385-391.
[15]	Zishuo Yi, Peng Liu, Yan Xu. Fluorescent “Chameleon”: A Popular Science Experiment Based on Dynamic Luminescence [J]. University Chemistry, 2024, 39(9): 304-310.

A Conversation with Semaglutide: Not a Miracle Drug

PDF

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 0