Abstract: This review provides a comprehensive examination of the Petasis-boronic acid-Mannich reaction, systematically elucidating its origin, reaction mechanism, research progress, and applications in organic synthesis. As a significant advancement in organoboron chemistry, this reaction represents an innovative extension of the traditional Mannich reaction and contributes to the enrichment of university-level organic chemistry curricula. By introducing the Petasis-boronic acid-Mannich reaction, this work aims to enhance students’ understanding of advanced organic reactions while fostering their interest and enthusiasm for exploring the field of organoboron chemistry, building upon their foundational knowledge of the classical Mannich reaction.

Key words: Petasis reaction, Organoboronic acid, Multicomponent reaction, Allylamine, Benzylamine