Abstract: Continuous flow reactions have gained widespread application in synthetic chemistry in recent years owing to their operational safety, high efficiency, and environmental friendliness. This experiment presents a continuous flow system employing polystyrene-immobilized 1,4-diazabicyclo[2.2.2]octane (DABCO) as a recyclable catalyst for the Knoevenagel condensation between 4-chlorobenzaldehyde and malononitrile, enabling the green and efficient synthesis of 2-(4-chlorobenzylidene)malononitrile. By integrating fundamental organic reactions from textbooks with contemporary research methodologies, this experiment not only reinforces students’ theoretical knowledge but also introduces innovative continuous flow technology to stimulate learning interest. The approach encourages students to optimize traditional organic synthesis processes, fostering the development of critical thinking and innovation skills in future chemists.

Key words: Continuous flow reaction, Knoevenagel condensation, Immobilized catalyst, Organic Synthesis