Abstract: Graphene, as the most representative two-dimensional material, demonstrates extensive application potential across energy, information technology, biological sciences, and environmental fields owing to its distinctive structure and superior properties. The undergraduate course “Advanced Graphene Materials and Applications” serves as an innovative seminar designed to systematically deliver fundamental graphene knowledge while conveying cutting-edge advancements, with the objective of cultivating students’ interdisciplinary innovation capabilities and practical skills. However, this course presents significant pedagogical challenges due to its highly interdisciplinary content, rapid knowledge updates, and difficulties in connecting theory with practice. Using our institution's graphene course as a case study, this paper proposes and implements an instructional reform approach integrating knowledge graph construction with research-education synergy. The reform features a three-tier knowledge graph framework encompassing “fundamental theories-preparation/characterization-frontier applications” to systematically organize fragmented graphene knowledge. Furthermore, it incorporates research projects, industrial requirements, and academic frontiers into case-based and project-based teaching modules. Preliminary implementation indicates this model effectively enhances course systematization, maintains content currency, and improves practicality, while significantly strengthening students’ knowledge integration capacity, research competence, and innovative thinking. This approach provides a replicable paradigm for cultivating top-tier innovative talents in advanced materials education.

Key words: Advanced graphene materials, Knowledge graph, Research-education integration, Interdisciplinary course