大学化学 >> 2026, Vol. 41 >> Issue (8): 331-338.doi: 10.12461/PKU.DXHX202507084

化学实验 上一篇    下一篇

创新实验——AIE分子聚集态调控及其糖胺聚糖模式识别应用

丁煜宾, 付艳林, 胡瑞月, 万华丽, 余佳欣, 吴磊   

  1. 南京农业大学理学院化学系, 江苏 南京 210095
  • 收稿日期:2025-07-21 录用日期:2025-09-15 发布日期:2026-08-25
  • 通讯作者: 吴磊 E-mail:rickywu@njau.edu.cn Lei Wu
  • 基金资助:
    南京农业大学研究生优质教学资源建设项目(NJAU-JPKC2024026,NJAU-JPKC2024027)

Innovation experiment: modulation of AIEgen aggregation states for pattern recognition of glycosaminoglycans

Yubin Ding, Yanlin Fu, Ruiyue Hu, Huali Wan, Jiaxin Yu, Lei Wu   

  1. Department of Chemistry, School of Science, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China
  • Received:2025-07-21 Accepted:2025-09-15 Published:2026-08-25
  • Contact: Lei Wu E-mail:rickywu@njau.edu.cn

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摘要： 聚集诱导发光分子在生物医学等领域应用广泛。本实验通过调控1-(4-羧基苯基)-1,2,2-三苯基乙烯在聚乙烯亚胺上的聚集状态构建荧光传感阵列用于复杂糖胺聚糖的模式识别。本实验帮助学生了解超分子化学、光化学、分析化学和医药领域交叉研究前沿，熟悉荧光光度计和酶标仪的使用，掌握从聚集诱导发光原理出发到实际检测应用的创新思路。

关键词: 聚集诱导发光, 聚乙烯亚胺, 模式识别, 糖胺聚糖, 综合实验

Abstract: Aggregation-induced emission (AIE) molecules have found extensive applications in biomedical research and related fields. This study develops a fluorescent sensor array by precisely controlling the aggregation states of 1-(4-carboxyphenyl)-1,2,2-triphenylethene on polyethyleneimine for pattern recognition of complex glycosaminoglycans. The experiment serves as an educational platform for students to explore cutting-edge interdisciplinary research spanning supramolecular chemistry, photochemistry, analytical chemistry, and pharmaceutical sciences. Participants will gain hands-on experience with fluorescence spectrophotometry and microplate reader operation, while mastering innovative approaches from fundamental AIE principles to practical detection applications.

Key words: Aggregation-induced emission, Polyethyleneimine, Pattern recognition, Glycosaminoglycan, Comprehensive experiment