大学化学 >> 2025, Vol. 40 >> Issue (11): 100-107.doi: 10.12461/PKU.DXHX202412133

教学研究与改革 上一篇    下一篇

基于线上线下混合式教学模式在高效液相色谱实验教学中的探索与实践

谢一凡1,2, 姚莉韵1,2, 杨若林2, 蔡玉兴1, 金玉杰1, 李宁1   

  1. 1 上海交通大学医学院, 基础医学实验教学中心, 上海 200025;
    2 上海交通大学医学院, 药物化学与生物信息学中心, 上海 200025
  • 收稿日期:2024-12-30 录用日期:2025-02-14 发布日期:2025-11-21
  • 通讯作者: 姚莉韵 E-mail:yaoliyun517@163.com Liyun Yao
  • 基金资助:
    上海交通大学医学院课程建设基金项目(BJ13000180095)

Exploration and Practice of Online and Offline Hybrid Teaching Mode in High-Performance Liquid Chromatography Experiment

Yifan Xie1,2, Liyun Yao1,2, Ruolin Yang2, Yuxing Cai1, Yujie Jin1, Ning Li1   

  1. 1 Basic Medical Experimental Teaching Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China;
    2 Medical Chemistry and Bioinformatics Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
  • Received:2024-12-30 Accepted:2025-02-14 Published:2025-11-21
  • Contact: Liyun Yao E-mail:yaoliyun517@163.com

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摘要： 高效液相色谱(HPLC)被广泛应用于生命科学研究、临床医学检验、药物研发、司法鉴定等领域。提升HPLC仪器操作的教学效果，对培养高素质、高技能的医学技术人才尤为重要。由于学生人数多、仪器少、不能重复操作等局限，导致学习效果受到影响。因此利用超星学习通、虚拟仿真实验等教学平台，将线上线下混合式教学融入其中，优化课前、课中、课后教学内容。通过任务驱动、线上自主学习、线下小组实操练习、课后总结和拓展知识，全面激发学生的积极性和主动性。实践结果表明，该教学模式能提升教学效果，受到学生欢迎。

关键词: 高效液相色谱, 线上线下混合式教学, 超星学习通, 虚拟仿真实验, 任务驱动

Abstract: High-performance liquid chromatography (HPLC) is extensively utilized across various domains including life science research, clinical medical testing, drug development, and forensic identification. Improving the instructional effectiveness of HPLC instrument operation is crucial for nurturing highly competent and skilled medical technology professionals. However, challenges such as a high student-to-instrument ratio, limited availability of equipment, and the inability to conduct repeated operations have adversely impacted learning outcomes. To address these issues, this study integrates a blended online and offline teaching approach into the HPLC experimental curriculum by leveraging platforms such as Chaoxing Learning and virtual simulation experiments. This method optimizes teaching content across pre-class, in-class, and post-class phases. By employing task-driven strategies, facilitating online self-learning, conducting offline group practical exercises, and encouraging post-class summaries and knowledge expansion, the approach aims to comprehensively enhance student engagement and initiative. Empirical results demonstrate that this teaching model significantly improves instructional effectiveness and is favorably received by students.

Key words: High-performance liquid chromatography, Online and offline hybrid teaching, Chaoxing learning platform, Virtual simulation experiment, Task-driven approach