大学化学 >> 2025, Vol. 40 >> Issue (4): 322-325.doi: 10.12461/PKU.DXHX202406016

所属专题： 化学科普(2025)

科普 上一篇    下一篇

车间一杯酒，中枢两行泪——都是双硫仑样反应惹的祸

梁一铭, 潘籽言, 陈建成   

  1. 1 南京大学安邦书院, 南京 210023;
    2 南京大学化学化工学院, 南京 210023
  • 收稿日期:2024-06-11 录用日期:2024-07-02 发布日期:2025-04-25
  • 通讯作者: 陈建成 E-mail:kschan@nju.edu.cn
  • 基金资助:
    南京大学百位名师邀约项目；南京大学国际化课程建设项目；南京大学短期国外专家项目

One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions

Yiming Liang, Ziyan Pan, Kin Shing Chan   

  1. 1 Anbang Academy, Nanjing University, Nanjing 210023, China;
    2 School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
  • Received:2024-06-11 Accepted:2024-07-02 Published:2025-04-25
  • Contact: Kin Shing Chan E-mail:kschan@nju.edu.cn

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摘要： 在“人体”工厂中，肝细胞车间主任“小灯”负责代谢乙醇、维护稳定。然而，随着糖尿病、失眠等疾病侵袭，中枢引入了安眠药、降压药等外援。小灯对药物与乙醛脱氢酶可能产生的双硫仑样反应缺乏警惕。一次意外中，头孢药物与乙醇代谢冲突，抑制了乙醛脱氢酶，导致乙醛肆虐，引发混乱。小灯意识到疏忽，加强安保，并向工人传达了领导指示，提醒大家在使用药物时需谨慎。此次危机虽得到控制，但肝细胞们更加明白责任与使命。我们也应从中汲取教训，珍惜生命，避免将生命安全置于危险之中。在表达感情时，有众多选择，完全不必过量饮酒。让我们共同守护这座神奇的工厂，确保它的安全与繁荣。

关键词: 双硫仑样反应, 酒精代谢, 药物与酒精互作

Abstract: In the “human body” factory, the director of the hepatocyte workshop, nicknamed “Xiaodeng”, manages ethanol metabolism to maintain stability. However, with the onset of diseases like diabetes and insomnia, the central nervous system introduces foreign aids such as sedatives and antihypertensive drugs. Xiaodeng inadvertently overlooks the potential disulfiram-like reaction between medications and aldehyde dehydrogenase. In an unfortunate incident, a conflict between cephalosporin drugs and ethanol metabolism inhibits acetaldehyde dehydrogenase, leading to acetaldehyde accumulation and ensuing chaos. Recognizing the oversight, Xiaodeng strengthens safety measures and instructs workers to exercise caution when using medications. Although the crisis is contained, this experience underscores the hepatocytes’ enhanced sense of responsibility and mission. We should learn from this and prioritize life, avoiding unnecessary risks such as excessive alcohol consumption. Let us unite in safeguarding this miraculous factory to ensure its safety and prosperity.

Key words: Disulfiram-like reaction, Alcohol metabolism, Drug-alcohol interactions