大学化学 >> 2026, Vol. 41 >> Issue (8): 350-362.doi: 10.12461/PKU.DXHX202507032

化学实验 上一篇    下一篇

近红外有机纳米粒子的合成及性质研究虚拟仿真实验

许馨予1, 欧昌金1, 孔春霞1, 田维亮2, 王化明3, 王海娇3, 陶涛1,2,3   

  1. 1 南京信息工程大学化学与材料学院, 江苏 南京 210044;
    2 塔里木大学化学化工学院, 新疆 阿拉尔 843300;
    3 新星职业技术学院能源化工系, 新疆 新星 839000
  • 收稿日期:2025-07-03 录用日期:2025-08-19 发布日期:2026-08-25
  • 通讯作者: 陶涛 E-mail:taotao@nuist.edu.cn Tao Tao
  • 基金资助:
    国家自然科学基金(21501097)；江苏省自然科学基金(BK20201389)；长三角高水平行业特色大学联盟重点课题(CSJZD202407)；南京信息工程大学教学改革研究课题(2023XYBJG10)

Virtual simulation experiment for the synthesis and properties of near-infrared organic nanoparticles

Xinyu Xu1, Changjin Ou1, Chunxia Kong1, Weiliang Tian2, Huaming Wang3, Haijiao Wang3, Tao Tao1,2,3   

  1. 1 School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu Province, China;
    2 College of Chemistry and Chemical Engineering, Tarim University, Alear 843300, Xinjiang Uygur Autonomous Region, China;
    3 Department of Energy and Chemical Engineering, Xinxing Vocational and Technical College, Xinxing 839000, Xinjiang Uygur Autonomous Region, China
  • Received:2025-07-03 Accepted:2025-08-19 Published:2026-08-25
  • Contact: Tao Tao E-mail:taotao@nuist.edu.cn

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摘要： 以近红外有机纳米粒子为代表的纳米生物材料，因具有精准靶向、疗效确切、成像分辨率高等优势，在肿瘤光治疗领域被广泛研究。但该研究涉及多学科交叉，且实验环节存在高危、高成本、高复杂性，真实条件下难引入本科教学。采用通用三维(U3D)虚拟现实技术平台将该研究转化为虚拟仿真实验，通过20步交互步骤和基于重要科学问题的引导式教学，促使学生主动深入思考，培养学生的科研思维，提升其解决复杂工程问题的综合能力，呈现出良好的直观教学效果。

关键词: 有机纳米粒子, 肿瘤光治疗, 电荷转移复合物, 虚拟仿真实验

Abstract: Near-infrared (NIR) organic nanoparticles, as representative nanobiomaterials, have attracted extensive research attention in tumor phototherapy owing to their precise targeting capability, well-defined therapeutic efficacy, and superior imaging resolution. However, this interdisciplinary research involves high-risk procedures, substantial costs, and considerable experimental complexity, rendering its direct implementation in undergraduate education impractical. Utilizing U3D virtual reality technology, we have converted this research into a virtual simulation experiment featuring a 20-step interactive procedure combined with guided inquiry-based learning centered on key scientific questions. This pedagogical approach stimulates students' critical thinking, fosters scientific research competencies, enhances their ability to solve complex engineering problems, and demonstrates excellent visual teaching outcomes.

Key words: Organic nanoparticles, Tumor phototherapy, Charge-transfer complexes, Virtual simulation experiment