University Chemistry ›› 2025, Vol. 40 ›› Issue (4): 277-281.doi: 10.12461/PKU.DXHX202407017

Special Issue:

• Survey of Chemistry • Previous Articles     Next Articles

Electrochemically Driven Denitrative Borylation and Fluorosulfonylation of Nitroarenes

Zhongyan Cao1, Youzhi Xu1, Menghua Li1, Xiao Xiao3, Xianqiang Kong4, Deyun Qian2   

  1. 1 College of Chemistry and Molecular Sciences, Henan University, Kaifeng 475004, Henan Province, China;
    2 Yunnan Key Laboratory of Research and Development for Natural Products, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education;School of Pharmacy, Yunnan University, Kunming 650500, China;
    3 Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China;
    4 School of Chemical Engineering and Materials, Changzhou Institute of Technology, Changzhou 213032, Jiangsu Province, China
  • Received:2024-07-01 Accepted:2024-09-02 Published:2025-04-25
  • Contact: Xianqiang Kong, Deyun Qian E-mail:kongxq@czu.cn;dyqian@ynu.edu.cn

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Abstract: Nitroarenes are widely utilized in organic synthesis and are a key topic in undergraduate organic chemistry curricula. However, efficient methods for denitrative transformations of nitroarenes under mild conditions remain limited. In recent years, green electrochemical synthesis has emerged as a promising approach for the selective C―N bond transformations of nitroarenes. This mini-review highlights recent advances in electrochemically facilitated denitrative transformations of nitroarenes, using reaction examples that are accessible to undergraduate students. These examples aim to expand students’ understanding of denitrative processes, stimulate their interest in the field, enhance their learning experience, and enrich their knowledge base.

Key words: Nitroarenes, Denitrative transformation, Electrosynthesis, Aryl boronates, Aryl sulfonyl fluorides