浅谈2018年诺贝尔化学奖:驾驭进化的力量

doi:10.3866/PKU.DXHX201811008

Abstract

Abstract:

In living organisms, protein functions are constantly evolving over generations throughout the history. Through iterative rounds of genetic mutations and natural selection of fit phenotypes, protein functions have been gradually optimized. This process could be mimicked and even greatly accelerated in the laboratory, when the selection pressure is directly applied to biomolecules of interest, which forms the basis of a technique called directed evolution. The Nobel Prize in chemistry 2018 was awarded jointly to Frances Arnold, George Smith and Gregory P. Winter for their pioneering contributions to the development and applications of directed evolution. Here we briefly review the history of this technique and its impact on renewable energy and pharmaceutical industry.

Key words: Directed evolution, Enzyme, Antibody, Phage display, Nobel Prize in chemistry

Ying ZHOU,Liyuan ZHU,Peng ZOU. A Brief Introduction to Nobel Prize in Chemistry 2018: Harnessing the Power of Evolution[J].University Chemistry, 2019, 34(1): 1-6.

References

1	Eigen M. ; Gardiner W. Pure Appl. Chem. 1984, 56, 967.
2	Chen K. Q. ; Arnold F. H. Proc. Natl. Acad. Sci. USA 1993, 90, 5618.
3	Coelho P. S. ; Brustad E. M. ; Kannan A. ; Arnold F. H. Science 2013, 339, 307.
4	Prier C. K. ; Hyster T. K. ; Farwell C. C. ; Huang A. ; Arnold F. H. Angew. Chem. In. Ed. 2016, 55, 4711.
5	Kan S. B. J. ; Huang X. Y. ; Gumulya Y. ; Chen K. ; Arnold F. H. Nature 2017, 552, 132.
6	Kan S. B. J. ; Lewis R. D. ; Chen K. ; Arnold F. H. Science 2016, 354, 1048.
7	Glieder A. ; Farinas E. T. ; Arnold F. H. Nat. Biotechnol. 2002, 20, 1135.
8	Schmidt-Dannert C. ; Umeno D. ; Arnold F. H. Nat. Biotechnol. 2000, 18, 750.
9	Savile C. K. ; Janey J. M. ; Mundorff E. C. ; Moore J. C. ; Tam S. ; Jarvis W. R. ; Colbeck J. C. ; Krebber A. ; Fleitz F. J. ; Brands J. ; Devine P. N. ; Huisman G. W. ; Hughes G. J. Science 2010, 329, 305.
10	Kohler G. ; Milstein C. Nature 1975, 256, 495.
11	Winter G. ; Milstein C. Nature 1991, 349, 293.
12	Bradbury A. R. ; Sidhu S. ; Dubel S. ; McCafferty J. Nat. Biotechnol. 2011, 29, 245.
13	Konthur Z. ; Hust M. ; Dubel S. Gene 2005, 364, 19.
14	Wang H. ; Yu R. ; Fang T. ; Yu T. ; Chi X. ; Zhang X. ; Liu S. ; Fu L. ; Yu C. ; Chen W. Toxins (Basel) 2016, 8, 266.
15	Ohara R. ; Knappik A. ; Shimada K. ; Frisch C. ; Ylera F. ; Koga H. Proteomics 2006, 6, 2638.
16	Smith G. P. Science 1985, 228, 1315.
17	McCafferty J. ; Griffiths A. D. ; Winter G. ; Chiswell D. J. Nature 1990, 348, 552.
18	Hentrich C. ; Ylera F. ; Frisch C. ; Ten Haaf A. ; Knappik A. Handbook of Immunoassay Technologies; Academic Press:London 2018, pp 47- 80.
19	Jespers L. S. ; Roberts A. ; Mahler S. M. ; Winter G. ; Hoogenboom H. R. Biotechnology 1994, 12, 899.
20	Frenzel A. ; Kugler J. ; Helmsing S. ; Meier D. ; Schirrmann T. ; Hust M. ; DubelS. Transfus Med Hemother 2017, 44, 312.
21	Frenzel A. ; Schirrmann T. ; Hust M. MAbs 2016, 8, 1177.
22	Daugherty P. S. Curr. Opin. Struct. Biol. 2007, 17, 474.
23	Boder E. T. ; Wittrup K. D. Nat. Biotechnol. 1997, 15, 553.

[1]	Mengting Liu, Shufen Yang, Yu Xue, Jiayan Zang, Quanyan Su, Xingye Zheng, Qiue Cao, Chuanhua Zhou. Preparation of Prussian Blue Analogs Derived Nanoenzymes and Their Enzymatic Catalytic Reaction Kinetics: A Comprehensive Analytical Chemical Experiment [J]. University Chemistry, 2023, 38(9): 163-171.
[2]	Senhai Zeng, Yuyan Bao, Ao Cao, Xiaoqiang Huang. Rational Evolution of a Fatty Acid Photodecarboxylase for Highly Selective Photodecarboxylation of trans Fatty Acid [J]. University Chemistry, 2023, 38(4): 243-252.
[3]	Hengyu Li, Chengyang Lai, Amelia Siqi Huang, Xing Chen. Basics and Frontiers of Click Chemistry and Bioorthogonal Chemistry: A Brief Introduction to 2022 Nobel Prize in Chemistry [J]. University Chemistry, 2023, 38(1): 1-7.
[4]	Yi Wu, Rui Liu, Yi Lv. Renaissance of Gemtuzumab Ozogamicin [J]. University Chemistry, 2022, 37(9): 2206066-.
[5]	Jin Yuan, Jingcheng Hao. Chemistry is the Basis of Human Survival and Development: Taking the Nobel Prize in Chemistry as a Route [J]. University Chemistry, 2022, 37(1): 2105027-.
[6]	Xiangqing Feng, Haifeng Du. The 2021 Nobel Prize in Chemistry: The Simpler the Better [J]. University Chemistry, 2022, 37(1): 2112014-.
[7]	Yuzi Huang, Maosheng Jiang, Yuexu Lin. Experimental Design and Teaching Effect of Maltose Syrup Preparation [J]. University Chemistry, 2021, 36(8): 2011034-.
[8]	Lingling Feng, Qiong Chen, Yumeng Li, Jinghan Liang, Zhou Wang. Preparation of an Important Enzyme FBP/SBPase from Cyanobacteria and Analysis of Interaction between Target Enzyme and Ligand: One Comprehensive Experiment Based on Research [J]. University Chemistry, 2021, 36(6): 2006087-.
[9]	Xian Wang, Lin Li. The Combination of Scientific Knowledge and Scientific Spirit: Taking the University General Course "Approaching the Nobel Prize in Chemistry (Bilingual Course)" as an Example [J]. University Chemistry, 2021, 36(3): 2007059-.
[10]	Hailong Yang, Yun Liu, Bin Yang. Structures and Interactions of SARS-CoV-2's Spike Protein and Its Receptor [J]. University Chemistry, 2020, 35(12): 2-8.
[11]	Xuran Niu, Zhuo Zhou, Wensheng Wei. A Brief Introduction to Nobel Prize in Chemistry 2020: Gene Editing for the Future [J]. University Chemistry, 2020, 35(12): 118-126.
[12]	Yunhui Huang. Nobel Prize for Lithium-Ion Battery and the Scientific Spirit [J]. University Chemistry, 2020, 35(1): 1-6.
[13]	Xinyu MA,Zhipeng A. WANG,Jie TIAN,Zhenxiong JIANG,Hanjie JIANG,He SUN,Qingxuan ZHOU,Xin WANG. Discussion on the Definition of "Irreversible" Reactions and Its Related Concepts in Biochemistry [J]. University Chemistry, 2019, 34(4): 77-83.
[14]	Lei GAO,Xinshui YU,Xiaoguang LEI. Biosynthesis of Natural Products: Exploring the Secret of How Nature Produces the Secondary Metabolites [J]. University Chemistry, 2019, 34(12): 45-53.
[15]	Yitao KE,Ning ZHANG,Yifan WANG,Di WU,Jiabei ZHOU. Were I Stone: Equilibrium of Precipitation and Dissolution in Arthrolithiasis [J]. University Chemistry, 2018, 33(7): 81-83.

A Brief Introduction to Nobel Prize in Chemistry 2018: Harnessing the Power of Evolution

RichHTML

PDF

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 0