钌宝宝的自荐信——我是抗癌小战士

doi:10.3866/PKU.DXHX201905013

Abstract

Abstract:

Using the anthropomorphic approach, this article introduces the discovery history of ruthenium elements in the first person role, and focuses on the ruthenium complexes as important therapeutic agents for cancer treatment. We have focused our attention on KP1019 incorporating ruthenium ions complexes which have been already used in clinical or have been advanced to clinical trials as anticancer agents. Moreover, the half-sandwich ruthenium and ruthenium polypyridine complexes drugs are also reviewed.

Key words: Ruthenium, Complex, Anticancer

Wen MA,Weiguo JIA. Self-Recommendation Letter of Baby Ruthenium: I Am an Anticancer Warrior[J].University Chemistry, 2019, 34(8): 47-50.

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References 12

1	Rosenberg B. ; Van Camp L. ; Trosko J. E. ; Mansour V. H. Nature 1969, 222, 385. doi: 10.1038/222385a0
2	Wong E. ; Giandomenico C. M. Chem. Rev. 1999, 99, 2451. doi: 10.1021/cr980420v
3	Hartinger C. G. ; Zorbas-Seifried S. ; Jakupec M. A. ; Kynast B. ; Zorbas H. ; Keppler B. K. J. Inorg. Biochem. 2006, 100, 891. doi: 10.1016/j.jinorgbio.2006.02.013
4	Bergamo A. ; Sava G. Dalton Trans. 2007, 13, 1267.
5	Kenny R. G. ; Marmion C. J. Chem. Rev. 2019, 119, 1058. doi: 10.1021/acs.chemrev.8b00271
6	Notaro A. ; Gasser G. Chem. Soc. Rev. 2017, 46, 7317. doi: 10.1039/C7CS00356K
7	张小年; 刘亚楠; 杨晓新; 刘杰. 化学进展, 2011, 23 (5), 983.
8	Wang X. D. Genes Dev. 2001, 15, 2922.
9	陈禹; 杜可杰; 巢晖; 计亮年. 化学进展, 2009, 21 (5), 836.
10	Weiss A. ; Berndsen R. H. ; Dubois M. ; Müller C. ; Schibli R. ; Griffioen A. W. ; Dyson P. J. ; Nowak-Sliwinska P. Chem. Sci. 2014, 5, 4742. doi: 10.1039/C4SC01255K
11	Hartinger C. G. ; Metzler-Nolte N. ; Dyson P. J. Organometallics 2012, 31, 5677. doi: 10.1021/om300373t
12	Schatzschneider U. ; Niesel J. ; Ott I. ; Gust R. ; Wölfl H. A. ChemMedChem 2008, 3 (7), 1104. doi: 10.1002/cmdc.v3:7

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Self-Recommendation Letter of Baby Ruthenium: I Am an Anticancer Warrior

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