University Chemistry ›› 2021, Vol. 36 ›› Issue (4): 2005074.doi: 10.3866/PKU.DXHX202005074

• Survey of Chemistry • Previous Articles     Next Articles

Progress on the Study on Synthetic Method of (2R, 3R)-1, 4-Dimethoxy-1, 1, 4, 4-Tetraphenylbutane-2, 3-Diol

Xiaoyun Hu1,*(), Zixing Shan2   

  1. 1 College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China
    2 College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
  • Received:2020-05-28 Accepted:2020-06-29 Published:2020-07-21
  • Contact: Xiaoyun Hu E-mail:xyhu@mail.scuec.edu.cn

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Abstract:

(2R, 3R)-1, 4-dimethoxy-1, 1, 4, 4-tetraphenylbutane-2, 3-diol has diverse applications in asymmetric organic synthesis, and this paper briefly introduces the progress on its synthetic methods from the perspective of green chemistry. Our group developed new synthetic methods based on the region-selective transformation of (2R, 3R)-1, 1, 4, 4-tetraphenylbutanetetraol. In the preparation, methanol was used as a methylating reagent and common inorganic alkali liquor was used instead of DDQ and LiAlH4.

Key words: (2R, 3R)-1, 4-dimethoxy-1, 1, 4, 4-tetraphenylbutane-2, 3-diol, (2R, 3R)-1, 1, 4, 4-tetraphenylbutanetetraol, Region-selective reaction