University Chemistry ›› 2022, Vol. 37 ›› Issue (12): 2111012.doi: 10.3866/PKU.DXHX202111012

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Discussion on the Definition and Improving Strategies of Selectivity in Analytical Chemistry

Liang Shi1, Honglan Qi2, Lu Zhang3, Chengxiao Zhang2,*()   

  1. 1 School of Electronic Information Engineering, Xi'an Technological University, Xi'an 710021, China
    2 School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China
    3 Technology Centre of Xi'an Customs District P. R. China, Xi'an 710068, China
  • Received:2021-11-03 Accepted:2022-02-22 Published:2022-03-17
  • Contact: Chengxiao Zhang


The selectivity is one basic parameter for evaluating analytical method. The International Union of Pure and Applied Chemistry (IUPAC) clearly recommends that the selectivity refers to the extent to which the method can be used to determine particular analytes in mixtures or matrices without interferences from other components of similar behavior. However, its definition and quantitation have still remained open questions. Here, the selectivity on the intrinsic characteristics (definitions), the types of interferences, and the estimation of sensitivity are discussed. Some strategies to improve the selectivity are summarized.

Key words: Selectivity, Interferences, Selectivity coefficient, Chemical measurement