Abstract:

An experiment was designed to replace benzene with aniline as the raw material in the preparation of p-aminoacetophenone by Friedel-Crafts acylation. In addition to the safety benefits, this modification challenges the students' ability to continuously synthesize the target product in multiple steps; encourages the students to think about the application of amino protection during synthesis; promotes the use of scientific methods and thinking.

Key words: Friedel-Crafts acylation, Aniline, Acetophenone