镓元素在医疗卫生领域的应用：以抗癌与抗菌为例

doi:10.3866/PKU.DXHX202203050

Abstract

Abstract:

Gallium is located at the fourth period and the IIIA group. It plays a significant role in clinical diagnosis and treatment of various diseases. Ga(Ⅲ) usually acts as a competitive inhibitor of Fe(Ⅲ) in organisms, as it shares most chemical characteristics except redox activity with Fe(Ⅲ). It can disrupt iron homeostasis in tumor or in microorganisms, thereby achieving antineoplastic or anti-microbial effects. In the aspect of cancer diagnosis and treatment, Ga(Ⅲ) can be taken up by cells through transferrin or independent transportation. On the one hand, its radioactive isotope (⁶⁷Ga or ⁶⁸Ga) concentrates in cancer tissues, realizing radiographic diagnosis of tumors. On the other hand, non-radioactive gallium kills cancer cells by inhibiting the normal function of ribonucleotide reductase (RR) and causing mitochondrial oxidative stress. In terms of antibacterial activity, Ga competes with Fe in biochemical reactions which enables it to destroy biofilms of bacteria and cause their death. In this review, we introduce the application of gallium in antineoplastic and antibacterial fields with the chemical mechanism revealed. And the development of Ga-based drugs will also be expected.

Key words: Gallium, Metallodrugs, Antineoplastic, Anti-microbial

Xinxin Peng, Lizhi Xu, Jiayi Zhang, Yanbo Jing, Songlin Tian, Yinghan Wu, Runyu Cao, JunLong Zhang. Gallium's Application in Medicine and Hygiene: Examples of Antineoplastic and Anti-Microbial[J].University Chemistry, 2022, 37(3): 2203050.

Figures/Tables 7

References 63

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元素	八面体场离子半径/?	四面体场离子半径/?	电子亲和能/eV	电离能/eV	电负性	第一水合常数	氢氧化物溶度积常数K_sp	氧化还原活性
Ga³⁺	0.62	0.47	30.71	64.0	1.81	11.40	1.4 × 10⁻³⁴	氧化还原惰性
Fe³⁺	0.65 (高自旋)	0.49 (高自旋)	30.65	54.8	1.83	11.83	2.8 × 10⁻³⁹	氧化还原活性

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Gallium's Application in Medicine and Hygiene: Examples of Antineoplastic and Anti-Microbial

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