University Chemistry ›› 2023, Vol. 38 ›› Issue (1): 111-118.doi: 10.3866/PKU.DXHX202203077

• Survey of Chemistry • Previous Articles     Next Articles

Research Progress in Achmatowicz Rearrangement Reaction

Wangze Song, Wenfeng Jiang()   

  • Received:2022-03-28 Accepted:2022-04-29 Published:2022-04-29
  • Contact: Wenfeng Jiang E-mail:jiangwf@dlut.edu.cn

Abstract:

The Achmatowicz rearrangement reaction is an important organic reaction that is based on a unique oxidative rearrangement mechanism. The reaction is widely used in organic synthesis, medicinal chemistry, and other fields, and its products are important fine chemicals that are widely used in the total synthesis of complex natural products. This article reviews the mechanism underlying the Achmatowicz rearrangement reaction and its research progress, including bromine and peroxidation and participation of high valence metal oxidants, photo promotion, and enzyme-catalyzed Achmatowicz rearrangement reaction. Moreover, the future development and opportunities in this field are discussed.

Key words: Achmatowicz rearrangement reaction, Oxidative rearrangement reaction, Research progress