Abstract: The rapid advancement of artificial intelligence (AI) and automation has transformed the way chemistry is researched. Data-driven scientific research, also known as the “fourth paradigm”, is now being applied to reaction prediction, chemical synthesis and analytical chemistry. Digital simulations, high-throughput virtual screening and AI-assisted analysis, along with automated laboratories, reduce both time and economic costs while significantly improving efficiency. This shift elevates chemists from “chemical laborer” to “innovative leaders”. This article examines the application of the fourth paradigm in chemistry, using examples from reaction prediction, synthesis and analytical chemistry. It discusses the evolving roles and responsibilities of chemists within this framework and explores the challenges of chemical education, including AI-integrated teaching reforms and the training of future chemists.

Key words: High-throughput, Artificial intelligence, The fourth paradigm, The changing role of chemists, Innovative leaders