Abstract: Basic chemistry is a core course for cultivating top-tier talent in science and engineering. However, textbook content often lags behind disciplinary advances, limiting its ability to foster scientific thinking, innovation capability, and interdisciplinary perspective. To address this issue, Beihang University has developed a four-dimensional teaching framework encompassing “fundamental theory-technical approaches-problem inquiry-disciplinary applications” within the context of the“101 Plan” and elite talent training system. This framework forms a teaching model that integrates “classics with frontiers” and “theory with case studies”. Following the developmental logic of chemical knowledge, the course incorporates representative cases such as the “evolution of hydrogen bond structures”, guiding students from mastering fundamentals toward exploring scientific frontiers and practical applications. Teaching practice shows that this model effectively enhances students’ classroom engagement and research motivation, strengthens their critical and innovative thinking, and provides valuable insights for reforming undergraduate chemistry education and cultivating innovative talents in science and engineering.

Key words: Basic chemistry teaching, Integration of research and education, Hydrogen bond structures, Elite talent cultivation