University Chemistry ›› 2022, Vol. 37 ›› Issue (7): 2109051.doi: 10.3866/PKU.DXHX202109051

• Survey of Chemistry • Previous Articles     Next Articles

Research Advances in the Dehydration and Ring-Closure Reaction for Flavonoids

Shui Hu, Houjin Li(), Rong Lai, Kejia Zhu, Min Peng, Lianyun Li   

  • Received:2021-09-16 Accepted:2021-11-05 Published:2021-12-10
  • Contact: Houjin Li E-mail:ceslhj@mail.sysu.edu.cn

Abstract:

Flavonoids play an important role in medicine, and its chemical synthesis is the research hotspot. Flavonoids are usually synthesized by the dehydration and ring closure of β-propanedione. However, the traditional method has several defects, such as long reaction time, low yield and difficulty in separation. Development of more efficient and more environmental friendly synthetic methods is imperative. Herein, we summarize the recent research progresses in the preparation of flavonoids by dehydration and ring-closure reactions under different conditions.

Key words: Flavonoid, β-propanedione, Dehydration, Ring-closure reaction