经典Hofmann消除反应的机理探究

doi:10.12461/PKU.DXHX202510104

Abstract

Abstract: This paper evaluates the mechanisms of the classic Hofmann elimination, especially the elimination reaction of cyclic quaternary ammonium hydroxide. When there are two trans-coplanar β-H, the hydrogen on the carbon with more substituents tends to be eliminated, resulting in the main product being an olefin with Zaitsev selectivity. This conclusion is also supported by DFT study result.

Key words: Quaternary ammonium hydroxide, Hofmann elimination, Zaitsev selectivity, Hofmann selectivity

Hongyu Cheng, Ruiyao Wang, Xingwen Sun. Mechanistic Study of the Classic Hofmann Elimination Reaction[J].University Chemistry, 2025, 40(12): 187-191.

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Mechanistic Study of the Classic Hofmann Elimination Reaction

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