Abstract: This article provides an overview of the general chemistry curriculum at Harvard University, with particular emphasis on the use of Professor James G. Anderson’s textbook, University Chemistry: Foundations and Frontiers from a Global and Molecular Perspective, in Physical Sciences 11 (PS 11) more than a decade ago. The unique structure of Harvard’s general chemistry sequence is introduced, detailing the range of courses available to first-year students with varying backgrounds in chemistry and biology, as well as the rationale for their design. The article highlights PS 11, a general chemistry course that integrates fundamental chemical principles with global issues in climate change and energy, making use of real-world applications to optimize conceptual learning. The curriculum’s core features, including its context-driven content and case studies are discussed. Reflections on the benefits and challenges of this integrated approach are shared, emphasizing how focused, context-based teaching can foster student motivation, deepen understanding, and prepare students to apply chemical knowledge broadly across scientific and societal challenges.

Key words: General chemistry, Course design, Global perspective, Molecular level