Abstract: Inorganic synthetic chemistry is a core module of the inorganic chemistry course under the Chemistry “101 Plan”, undertaking the key mission of cultivating students’ innovative thinking and knowledge application ability. To address key challenges in current teaching such as difficult understanding of abstract concepts, disconnection between theory and practice, and weak cultivation of scientific research thinking, this paper proposes a teaching method of “case-driven, multi-dimensional integration, and ability progression” based on the top-tier talent cultivation concept of the Chemistry “101 Plan”. It adopts five approaches: concrete anchoring of abstract principles, introduction through life scenarios, story-telling of classic cases, discussion-based inquiry, and connecting cutting-edge trends with interdisciplinary cases. Through these approaches, classic and frontier scientific research achievements are deeply integrated with basic teaching content. Practice shows that this teaching mode effectively reduces the threshold of knowledge understanding, stimulates students’ learning interest, and significantly improves their knowledge application ability and scientific research thinking literacy, providing a replicable and promotable practical paradigm for the teaching reform of inorganic synthetic chemistry under the Chemistry “101 Plan”.

Key words: Chemistry “101 Plan”, Inorganic chemistry, Case-driven teaching, Teaching innovation, Cultivation of top-notch talents