Abstract: To address the key challenges in traditional interdisciplinary training for chemistry undergraduates—such as disjointed knowledge integration, theory-practice disconnects, and insufficient innovation translation—the School of Chemistry and Life Sciences at Nanjing University of Posts and Telecommunications has developed a closed-loop cultivation model based on the core curriculum framework of the Chemistry “101 Plan”. Through systematic integration of “basic course optimization + interdisciplinary module embedding”, this model fully meets the core requirements of the Chemistry “101 Plan” in three aspects: core course optimization, research-driven teaching enhancement, and elite talent cultivation. Leveraging a diversified curriculum system, precision-based mentoring, and comprehensive industry-education integration, the model facilitates a natural progression through “knowledge acquisition, practical innovation, and teaching iteration” to strengthen students’ multidimensional innovative capabilities. Implementation results demonstrate significant outcomes: substantial increases in undergraduate research participation rates, exceptional academic outputs and competition achievements, pronounced teaching feedback effects, and marked improvements in graduate career readiness. This model provides a replicable interdisciplinary education paradigm for regional universities to implement the Chemistry “101 Plan” while leveraging their distinctive strengths.

Key words: Chemistry “101 Plan”, “Three-Three” talent cultivation, Full-scale undergraduate tutorial system, Flexible electronics, Interdisciplinary closed-loop cultivation