A small proportion of nephropathy patients administered gadolinium contrast agents for nuclear magnetic resonance have been reported to develop nephrogenic systemic fibrosis (NSF). This paper introduces the mechanism of the transformation and deposition of NSF, aiming to reveal the chemical nature of the gadolinium phosphate bioparticles in nephrogenic system fibrosis. This research will provide an important theoretical basis for future studies on the occurrence, development, and formation of nephrogenic system fibrosis and the removal of sediment residues. Moreover, a new idea for introducing a biocompatible second chelating agent into the gadolinium contrast agent system has been proposed, which aims to improve the safe use of gadolinium contrast agent.

The COVID-19, AIDS, influenza, and other infectious viral diseases have a significant impact on human health, and new antiviral drugs are continuously emerging to combat these diseases. Herein, aiming at anti-SARS-CoV-2, anti-HIV, and anti-influenza virus, the latest research progress of small-molecule drugs is reported in this paper. The discovery process, mechanism of action, synthesis process, and structure–activity relationship research of each drug are systematically expounded to promote antiviral drug research and development.

With the rapid development of modern medical technology, people are gaining understanding of the causes of diseases and the mechanisms of drug action. The simple macro thinking mode of the Traditional Chinese Medicine (TCM) is challenging to adapt to the needs of TCM teaching and development in the new era; this indicates that there is an urgent need to introduce new teaching methods and models. The chemical components of the TCM and its prescription are the material basis for its clinical efficacy in preventing and treating diseases. Therefore, under the guidance of the TCM theory, this paper integrates Chinese medicine chemistry into the teaching and practice of the TCM by considering Rhei Radix Et Rhizoma as an example with respect to anthraquinones. Through the three dimensions teaching of theory, practice, and expansion, students' cognition and application ability related to the TCM were shown to be effectively improved, and the integration was proven to promote the cultivation of compound TCM talents.

Teaching medicinal chemistry in English plays a crucial role in cultivating international and innovative pharmaceutical talents. This study, based on the practical work of teaching medicinal chemistry in English, identified the pain points of this practice, such as limited and abstract teaching content and the limited teachers' level. Moreover, adhering to the concept of "student-centered and international-oriented" teaching, this study entailed an innovative practice research on teaching medicinal chemistry in English from the perspectives of teaching staff, teaching content, and teaching methods. It was revealed that, to improve the quality of teaching, this practice should focus on an innovative international teaching system based on the following four aspects: teaching team building, teaching methods, curriculum system, and teaching materials.

The Comprehensive Science Training Experiment is a crucial component in the cultivation of top-notch talents in the field of scientific innovation. This article introduces a comprehensive experiment on the synthesis and characterization of a star-shaped polyamine in the organic chemistry science training course. Through this experiment, students can gain an understanding of the cutting-edge research and advancements in polyamine chemistry, apply their theoretical knowledge to design synthetic routes for target products, deepen their understanding of the basic principles and experimental methods of diazotization, Schiff base reaction, and Suzuki coupling reaction, master the techniques of monitoring reactions using thin-layer chromatography and separating products through column chromatography, and learn to characterize and identify compound structures using modern analytical methods such as nuclear magnetic resonance and infrared spectroscopy. This experiment not only cultivates students’ rigorous scientific attitude and research innovation consciousness but also trains their practical research skills. Furthermore, through diversified experimental approaches, it fosters students’ teamwork abilities, stimulates their enthusiasm, initiative, and creativity, and enhances their problem-analysis-and-solving capabilities.

In response to the issues in the teaching of the medicinal chemistry course, we propose an innovative teaching approach based on a higher-order skills-oriented advanced research-oriented learning model. By combining the P-MASE research-oriented learning model with advanced instructional activity design, we create a higher-order skills-oriented teaching activity that integrates "interesting case research + creative research activities + project challenges", and construct a teaching scenario that incorporates the instructional content. Under the guidance of teachers, students advance their research-oriented learning in medicinal chemistry through the P-MASE framework, which involves problem identification, method exploration, scientific analysis, effective solution, and evaluation of outcomes. This approach facilitates theoretical development and enhances students' research and innovation thinking skills. Through an analysis of the achievement of the medicinal chemistry course, it is confirmed that this model can effectively enhance the higher-order nature, innovation, and challenge of the course.

Chemical biology, a frontier scientific discipline that emerged in the late 20th century, delves into the chemical underpinnings of life phenomena at the molecular level, aiming to study and regulate biological processes. The course "Chemical Biology" encompasses diverse disciplines such as biology, chemistry, medicine, and pharmacy, highlighting its distinct characteristics as an emerging interdisciplinary field. The teaching team is closely aligned with a series of national education and academic excellence strategies such as deepening education and teaching reform, building world-class universities and world-class disciplines, etc., and puts forward the reform goal of "nurturing versatile and innovative talents and exploring the path of constructing interdisciplinary fundamentals courses". In practice, the team adheres to the reform concept of "multi-dimensional cross-fusion", implements the reform ideas of "one orientation, one guidance, and three guarantees", and practices ideological and political education with the core of "exploring the unknown and serving the country with science and technology". This provides a replicable path for the construction of cutting-edge interdisciplinary fundamentals courses and the cultivation of compound innovative talents for the country.

In recent years, the combination of surface and colloid chemistry with macrocyclic chemistry has garnered widespread attention among scientists. The integration of diverse macrocyclic structures into surfactant molecules not only greatly enriches the diversity of surfactants, but also imparts them with the host-guest recognition functionality of macrocycles. Macrocyclic amphiphiles and supra-amphiphiles, developed from this approach, have demonstrated high potential in applications such as bioimaging and drug delivery. The evolution from traditional surfactants to macrocyclic amphiphiles and supra-amphiphiles underscores the importance of interdisciplinary integration in advancing scientific research.

Organic chemistry serves as a fundamental course in pharmaceutical studies, which is closely associated with medicinal chemistry and innovative drug research. With its multifarious and complex content, certain topics in organic chemistry, such as the theory of chemical bonding relevant to innovative drug design, can be abstract and challenging to comprehend. Integrating case studies from innovative drug research into organic chemistry classroom teaching, along with the use of relevant software to demonstrate the interactions between organic small molecules and biomacromolecules, can make these concepts more vivid, accessible, and engaging for students. Moreover, this approach deepens students' understanding of the relationship between organic chemistry and pharmacy, and ignites their interest and proactivity in learning, which ultimately enhances the overall teaching quality.

This article reviews research on antihypertensive medications including vasodilators, β-blockers, and angiotensin Ⅱ receptor antagonists that have been approved by the FDA (Food and Drug Administration) since 2011. It covers the discovery of lead compounds, mechanisms of action, structural modifications, structure-activity relationships, and synthesis methods, aiming to serve as a reference for the development of antihypertensive drugs.

Medicinal chemistry, as a fundamental course in undergraduate pharmacy programs, serves as the cornerstone of innovative drug research. Enhancing the timeliness, innovation, and advanced nature of medicinal chemistry teaching content to meet the demands of talent development in contemporary pharmaceutical innovation is a challenge warranting deep consideration and exploration. This paper, grounded in the teaching content of the cardiovascular system drugs chapter, constructs course cases that incorporate the frontiers of the discipline, interdisciplinary studies, and curriculum-based ideological and political education. It aims to provide new materials and perspectives for teaching in medicinal chemistry and related fields.

Innovative drug development is the central driving force of the pharmaceutical industry. Cultivating a large cohort of pharmacy undergraduates with a solid background in drug development research is of significant importance. Currently, the majority of educational institutions feature a disjointed approach between foundational courses and specialized pharmacy courses. This disconnection prevents students from integrating basic chemistry knowledge with innovative drug development research during their early academic years. As a result, students lose the opportunity to build a comprehensive understanding of drug development, thereby diminishing the appeal and formative potential of the education. This paper uses the teaching of coordination chemistry in inorganic chemistry as an example, attempting to incorporate structural visualization and case studies of innovative drugs into the curriculum. The goal is to elevate the subject matter's professionalism, innovation, and advanced nature to meet the demands of high-quality pharmaceutical talent development and to inspire undergraduates to engage in new drug research by bridging the gap between foundational and specialized courses. This teaching approach can be extended and applied to other courses like organic chemistry and medicinal chemistry.

Case-based teaching is an important lever for improving teaching quality. The collection and organization of case materials are crucial steps. This article takes pharmaceutical-related courses as an example, and combines with specific instances, summarizes common approaches for mining and organizing teaching case libraries.