大学化学 >> 2026, Vol. 41 >> Issue (6): 72-78.doi: 10.12461/PKU.DXHX202508064

所属专题: 化学“101计划”案例

专题 上一篇    

化学与生物融合的有机化学课程创新实践

吴国骄, 吴钰周, 袁伟明, 钟芳锐   

  1. 华中科技大学化学与化工学院, 湖北 武汉 430074
  • 收稿日期:2025-08-19 录用日期:2025-09-25 发布日期:2026-06-18
  • 通讯作者: 钟芳锐 E-mail:chemzfr@hust.edu.cn Fangrui Zhong

Bridging chemistry and biology: innovative practices in organic chemistry teaching

Guojiao Wu, Yuzhou Wu, Weiming Yuan, Fangrui Zhong   

  1. School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, Hubei Province, China
  • Received:2025-08-19 Accepted:2025-09-25 Published:2026-06-18
  • Contact: Fangrui Zhong E-mail:chemzfr@hust.edu.cn

摘要: 为响应教育部“101计划”对化学拔尖人才培养的要求,本研究聚焦有机化学与生物的深度交叉,探索课程教学创新实践。提出有机化学课程应融入化学生物学交叉融合的知识案例,通过从有机反应和分子机制的角度介绍前生命化学反应、生物有机中的酸碱催化反应、氧化还原反应,仿生和人工酶催化等内容,阐释生化反应中的酶作用机制与合成化学原理的辩证统一。融合化学生物交叉知识的课程设计,不仅能强化学生对有机反应本质的理解,也有助于培养其跨学科思维和创新能力,为新时代化学基础学科教学改革提供参考。

关键词: 学科交叉, 有机化学, 教学改革, 人才培养, 创新实践

Abstract: In response to the requirements of the Ministry of Education’s “101 Plan” for cultivating top-tier talents in chemistry, this study focuses on the deep integration of organic chemistry and biology, exploring innovative practices in curriculum teaching. We propose incorporating interdisciplinary knowledge merging chemistry and biology into the basic organic chemistry course. By introducing prebiotic chemical reactions, general acid-base catalysis, redox reactions in bioorganic systems, as well as biomimetic and artificial enzyme catalysis from the perspectives of organic reaction mechanisms and molecular principles, this approach elucidates the dialectical unity between enzymatic mechanisms and synthetic chemistry principles. The curriculum design integrating chemical-biological knowledge not only enhances students’ understanding of the essence of organic reactions but also cultivates interdisciplinary thinking and innovative abilities, providing a reference for reforming chemistry education in the new era.

Key words: Interdisciplinary integration, Organic chemistry, Teaching reform, Talent cultivation, Innovative practice