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经典方法与金属催化C-N偶联对比下的有机胺合成教学改革

邵稳, 陈伊, 王佳佳   

  1. 湘潭大学化学学院, 湖南 湘潭 411105
  • 收稿日期:2026-03-30 修回日期:2026-05-27
  • 通讯作者: 邵稳, 王佳佳 E-mail:shaowen@xtu.edu.cn;wangjiajia@xtu.edu.cn Wen Shao, Jiajia Wang
  • 基金资助:
    国家自然科学基金项目(22201239)；湖南省普通本科高校教学改革研究项目(202502000401)；湘潭大学学位与研究生教学改革研究项目(YJGYB20240034)；湘潭大学教学改革研究项目(湘大教发[2025]9号)

Teaching reform in organic amine synthesis: comparative analysis of classical methods and metal-catalyzed C-N coupling

Wen Shao, Yi Chen, Jiajia Wang   

  1. College of Chemistry, Xiangtan University, Xiangtan 411105, Hunan Province, China
  • Received:2026-03-30 Revised:2026-05-27
  • Contact: Wen Shao, Jiajia Wang E-mail:shaowen@xtu.edu.cn;wangjiajia@xtu.edu.cn

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摘要： 当前基础有机化学教学虽体系完整，但与学科前沿及工业应用存在脱节。本文以有机胺的合成为切入点，剖析传统方法在芳香胺及手性胺合成中的局限，通过对比传统胺类制备方法与金属催化C–N偶联技术的差异，并结合药物分子合成实例探讨将前沿成果融入本科教学的路径，旨在构建更具时代性的有机化学知识体系。

关键词: 有机化学, 金属有机化学, 教学改革, 胺, C-N键偶联

Abstract: Current foundational organic chemistry instruction, while systematic, is somewhat disconnected from cutting-edge research and industrial applications. Taking organic amine synthesis as a starting point, this article demonstrates the limitations of classical methods in the synthesis of aromatic and chiral amines. By comparing traditional amine preparation methods with metal-catalyzed C-N coupling technologies, and illustrating with cases from pharmaceutical synthesis, it dedicates to exploring pathways for integrating cutting-edge advancements into undergraduate teaching, aiming to construct a more contemporary knowledge framework in organic chemistry.

Key words: Organic chemistry, Organometallic chemistry, Teaching reform, Amines, C-N bond coupling