大学化学 >> 2019, Vol. 34 >> Issue (9): 106-109.doi: 10.3866/PKU.DXHX201902003

化学实验 上一篇    下一篇

含典型氟-氢邻近与远程耦合的混合物的核磁共振氢谱示例

黄艳,吴江林,庞振国,卢志云*()   

  • 收稿日期:2019-02-14 录用日期:2019-08-27 发布日期:2019-08-29
  • 通讯作者: 卢志云 E-mail:luzhiyun@scu.edu.cn
  • 基金资助:
    国家自然科学基金(21875148);四川大学未来教学项目

Examples of 1H NMR Spectra of Mixture of Compounds Containing Vicinal and Long-Range Fluorine-Proton Coupling

Yan HUANG,Jianglin WU,Zhenguo PANG,Zhiyun LU*()   

  • Received:2019-02-14 Accepted:2019-08-27 Published:2019-08-29
  • Contact: Zhiyun LU E-mail:luzhiyun@scu.edu.cn
  • Supported by:
    国家自然科学基金(21875148);四川大学未来教学项目

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摘要：

设计合成了两组含氟的四取代苯化合物，苯环上的两个氢分别与F构成邻位和间位。所得化合物经核磁共振氢谱确认后，均为混合物。两组混合物芳香区氢谱简单，但又极具典型性。每个化合物苯环上的两个质子的氢谱均清晰体现了氟对其的邻近及远程耦合。此外两组共混物，一组有谱图重叠，一组没有，也可以作为既典型又简洁的共混物氢谱示例。

关键词: 核磁共振氢谱, 氟, 氟-氢耦合, 混合物氢谱, 多取代苯

Abstract:

Two serials of tetrasubstituted benzene compounds containing fluoro group were designed and synthesized. The other three substitutes are sequentially the para, meta, and ortho to fluoro group. The obtained compounds were all mixtures as confirmed by 1H NMR spectroscopies. The spectra clearly show the proximity and remote interaction between fluorine atom and hydrogen atom. In addition, the two spectra, one showing the overlapping peaks, one not, can be used as the simple and typical example of 1H NMR spectra of mixtures.

Key words: 1H NMR spectroscopy, Fluorine, H-F coupling, 1H NMR spectra of mixtures, Multiple substituent benzene