大学化学 >> 2020, Vol. 35 >> Issue (3): 113-119.doi: 10.3866/PKU.DXHX201906058

师生笔谈 上一篇    下一篇

以去氢弯孢霉素NMR结构解析讲授本科生波谱分析课程

董建伟1,李雪娇1,蔡乐2,*(),缪应纯1   

  1. 1 曲靖师范学院化学与环境科学学院, 云南 曲靖 655011
    2 云南大学化学科学与工程学院, 昆明 650091
  • 收稿日期:2019-06-26 录用日期:2019-07-20 发布日期:2019-08-21
  • 通讯作者: 蔡乐 E-mail:caile@ynu.edu.cn
  • 基金资助:
    云南省研究生优质课程项目;曲靖师范学院教育教学改革研究项目(JGXM201809)

Teaching Undergraduate Student Curriculum "Spectral Analysis" by the NMR Analysis of Dehydrocurvularin

Jianwei Dong1,Xuejiao Li1,Le Cai2,*(),Yingchun Miao1   

  1. 1 College of Chemistry and Environmental Science, Qujing Normal University, Qujing 655011, Yunnan Province, P. R. China
    2 School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China
  • Received:2019-06-26 Accepted:2019-07-20 Published:2019-08-21
  • Contact: Le Cai E-mail:caile@ynu.edu.cn
  • Supported by:
    云南省研究生优质课程项目;曲靖师范学院教育教学改革研究项目(JGXM201809)

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摘要：

以去氢弯孢霉素核磁共振波谱（NMR）解析为例，讲授本科化学和药学相关专业波谱分析课程NMR解析。去氢弯孢霉素结构包含苯环、双键、酚羟基、羰基和酯基等常见基团，NMR信号几乎无重叠、辨识度高，非常适合作为核磁共振波谱结构解析中化学位移、耦合常数和二维核磁共振波谱的授课内容。

关键词: 波谱分析, 核磁共振波谱, 结构解析, 去氢弯孢霉素

Abstract:

This paper illustrates the teaching of the undergraduate curriculum "spectral analysis" by the NMR analysis of dehydrocurvularin. Dehydrocurvularin possesses several functional groups including benzene ring, double bond, phenolic hydroxyl, carbonyl, and ester group, and showed distinct and recognizable NMR signals, which is suitable for teaching of chemical shifts, coupling constants, and 2D NMR analysis.

Key words: Spectral analysis, Nuclear magnetic resonance spectrum, Structure elucidation, Dehydrocurvularin