大学化学 >> 2021, Vol. 36 >> Issue (4): 2005044.doi: 10.3866/PKU.DXHX202005044

化学实验 上一篇    下一篇

pH响应纳米粒子的制备及应用综合实验

刘阳(), 刘琦   

  • 收稿日期:2020-05-15 录用日期:2020-07-04 发布日期:2020-08-03
  • 通讯作者: 刘阳 E-mail:yliu@nankai.edu.cn
  • 作者简介:刘阳, Email: yliu@nankai.edu.cn
  • 基金资助:
    科技部重点研发专项“纳米科技”(2018YFA0209700)

Comprehensive Experiment on Preparation and Application of pH-Responsive Nanoparticles

Yang Liu(), Qi Liu   

  • Received:2020-05-15 Accepted:2020-07-04 Published:2020-08-03
  • Contact: Yang Liu E-mail:yliu@nankai.edu.cn

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摘要：

为了使学生更深入、直观地了解高分子材料在纳米领域的发展与应用前沿，设计了pH响应性纳米粒子的制备及应用综合实验。该综合实验包括开环聚合合成pH响应性嵌段聚合物、pH响应纳米粒子的制备、pH响应性表征及分析以及细胞摄取及细胞转染等实验内容，能够使学生充分了解高分子纳米药物的设计理论及其制备与表征相关的基本流程和操作方法。本实验涉及高分子学科在纳米医药领域的应用前沿，有利于培养学生的综合实验能力和问题分析能力，激发学生探索科研前沿的兴趣。

关键词: 高分子化学, 纳米医学, pH响应, 高分子材料

Abstract:

In order to provide students with a more in-depth and intuitive understanding of the development and application of polymer materials in the field of nanotechnology, a comprehensive experiment was designed to focus on the design and biomedical applications of a novel-structured pH-responsive nanoparticle. This comprehensive experiment includes the synthesis of a pH-responsive block co-polymer via ring-opening polymerization, preparation of pH-responsive nanoparticles, and characterization and analysis of the polymer and the nanoparticles. This experiment helps students to understand the design principle and the basic processes of the preparation and characterization of polymer nanomedicine. This experiment involves the application of polymer science in the field of nanomedicine, which helps students to cultivate the ability to analyze and solve scientific problems, and stimulates the interest in exploring the frontiers of scientific research.

Key words: Polymer chemistry, Nanomedicine, pH response, Polymer materials