大学化学 >> 2021, Vol. 36 >> Issue (9): 2106023.doi: 10.3866/PKU.DXHX202106023

所属专题： 分析化学课程与实验教学

师生笔谈 上一篇    下一篇

利用二维核磁解析复杂有机分子的结构

叶克印(), 张香归, 袁耀锋   

  • 收稿日期:2021-06-09 录用日期:2021-07-28 发布日期:2021-08-17
  • 通讯作者: 叶克印 E-mail:kyye@fzu.edu.cn
  • 作者简介:叶克印, Email: kyye@fzu.edu.cn
  • 基金资助:
    福建省本科高校教育教学改革研究项目;福州大学一流本科教学改革建设项目;中国高等教育理科教育专业委员会高等理科教育研究课题

Structural Analysis of Complex Organic Molecules by Two-Dimensional Nuclear Magnetic Resonance Spectroscopy

Keyin Ye(), Xianggui Zhang, Yaofeng Yuan   

  • Received:2021-06-09 Accepted:2021-07-28 Published:2021-08-17
  • Contact: Keyin Ye E-mail:kyye@fzu.edu.cn

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摘要：

二维核磁是解析复杂有机化合物结构、精确归属核磁信号的有效分析工具。本文结合实例介绍了二维核磁在解析复杂有机分子结构方面的应用。相较于一维核磁，二维核磁将化学位移、偶合常数等重要参数展开在二维平面上，不仅解决了一维核磁谱线拥挤重叠等问题，还能提供自旋核相互作用的信息。因此，学习和掌握好二维核磁，有利于提高学生解析复杂有机分子结构的能力。

关键词: 二维核磁, 复杂分子结构分析, 偶合常数

Abstract:

Two-dimensional NMR (2D NMR) is an effective tool for analyzing complex organic molecules and accurate assignments of their NMR signals. Herein, we showed three applications of 2D NMR on the structural analysis of complex molecules. Compared with 1D NMR, 2D NMR is advantageous due to the fact that it resolves the overlapped NMR signals much better by presenting those important parameters (chemical shifts and coupling constants, etc.) in two dimensions. In addition, 2D NMR provides the information of mutual-interactions of various nuclei. Therefore, 2D NMR can definitely help students to analyze the complex organic molecules.

Key words: 2D NMR spectroscopy, Structural analysis of complex molecules, Coupling constant