大学化学 >> 2026, Vol. 41 >> Issue (2): 353-359.doi: 10.12461/PKU.DXHX202505017

所属专题: 化学科普(2025)

科普 上一篇    下一篇

D-氨基酸与镜像蛋白质

郑直1, 刘飞扬1, 赵军龙2   

  1. 1 西北大学化学与材料科学学院, 化学国家级实验教学示范中心(西北大学), 西安 710127;
    2 西北大学医学院, 西安 710069
  • 收稿日期:2025-05-08 录用日期:2025-05-22 发布日期:2025-12-27
  • 通讯作者: 赵军龙 E-mail:zhaojunlong327@163.com Junlong Zhao
  • 基金资助:
    西安市社科规划项目(25JY135)

D-Amino Acids and Mirror-Image Proteins

Zhi Zheng1, Feiyang Liu1, Junlong Zhao2   

  1. 1 National Chemistry Experimental Teaching Demonstration Center, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China;
    2 School of Medicine, Northwest University, Xi'an 710069, China
  • Received:2025-05-08 Accepted:2025-05-22 Published:2025-12-27
  • Contact: Junlong Zhao E-mail:zhaojunlong327@163.com

摘要: 镜像蛋白质由D-氨基酸及甘氨酸构成,表现出与天然蛋白质截然不同的结构与功能,近年来引起了广泛关注。本文从生命同手性起源假说切入,介绍了镜像氨基酸及蛋白质的合成技术与应用场景,旨在让读者看到镜像分子对于社会发展的积极作用的同时,也能警惕镜像生命带来的潜在风险,做到理性看待镜像分子技术的发展。

关键词: 镜像蛋白质, D-氨基酸, 同手性, 镜像生命

Abstract: Mirror-image proteins, composed of D-amino acids and glycine, exhibit distinct structures and functions compared to natural proteins. Starting from the homochirality hypothesis of life’s origin, this article introduces synthetic methods and applications of mirror-image amino acids and proteins. While highlighting their positive societal impacts, we also address potential risks of mirror-image life, aiming to provide a balanced view on this technology’s development.

Key words: Mirror-image proteins, D-amino acids, Homochirality, Mirror-image life